Severe skin toxicity with organ damage under the combination of targeted therapy following immunotherapy in metastatic melanoma
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DOI: 10.1097/cmr.0000000000000472
Abstract: Targeted therapy combination (TTC: antiRAF+antiMEK) is known to improve metastatic melanoma survival. Few severe skin toxicities (grade ≥3) are described with first-line TTC (17% for vemurafenib+cobimetinib and none for dabrafenib+trametinib) in a phase III trial.… read more here.
Keywords: metastatic melanoma; targeted therapy; severe skin; skin ... See more keywords
Risk of Attacks by Blackflies (Diptera: Simuliidae) and Occurrence of Severe Skin Symptoms in Bitten Patients along the Eastern Border of the European Union
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DOI: 10.3390/ijerph19137610
Abstract: The components of blackfly (Diptera: Simuliidae) saliva secreted during feeding on humans and animals induce various pathological reactions manifested by skin lesions and systemic symptoms. In this study, we describe 43 cases of severe skin… read more here.
Keywords: insects; severe skin; european union; diptera simuliidae ... See more keywords