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   Articles with "severe ulcerative" as a keyword



Upadacitinib as rescue therapy for corticosteroid failure acute severe ulcerative colitis: an Asian experience from Taiwan

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recommendations! Published in 2025 at "International Journal of Colorectal Disease"

DOI: 10.1007/s00384-025-04825-w

Abstract: Acute severe ulcerative colitis (ASUC) is a medical emergent condition, and approximately one-third of patients with ASUC do not respond to corticosteroid. Whether small molecule drugs are efficient and safe for salvage therapy of ASUC… read more here.

Keywords: five 100; therapy; acute severe; severe ulcerative ... See more keywords
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Delayed Initiation of Rescue Therapy Associated with Increased Length of Stay in Acute Severe Ulcerative Colitis

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recommendations! Published in 2022 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-022-07490-z

Abstract: Reducing hospitalization length of stay (LOS) for acute severe ulcerative colitis (ASUC) will reduce healthcare costs, mitigate hospitalization-associated risks (e.g., venous thromboembolism), and improve quality of life. A chart review was performed of all adult… read more here.

Keywords: therapy; acute severe; initiation; severe ulcerative ... See more keywords
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Acute severe ulcerative colitis: management advice for internal medicine and emergency physicians

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recommendations! Published in 2021 at "Internal and Emergency Medicine"

DOI: 10.1007/s11739-021-02704-0

Abstract: Acute severe ulcerative colitis is a medical emergency that warrants in-patient management. This is best served within a multidisciplinary team setting in specialised centres or with expert consultation. Intravenous corticosteroids remain the cornerstone in the… read more here.

Keywords: medicine; acute severe; severe ulcerative; management ... See more keywords

Severe ulcerative colitis induced by COVID-19 vaccination

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recommendations! Published in 2024 at "Clinical Journal of Gastroenterology"

DOI: 10.1007/s12328-024-01926-x

Abstract: A 37-year-old woman developed severe colitis with diffuse mucosal erythema and ulcerations throughout the entire colon after the 3rd vaccination of COVID-19. Stool culture was negative, and the pathological findings showed increased lymphoplasmacytic and neutrophilic… read more here.

Keywords: colitis induced; severe ulcerative; covid vaccination; ulcerative colitis ... See more keywords

Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis.

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recommendations! Published in 2019 at "Gastroenterology"

DOI: 10.1053/j.gastro.2018.11.035

Abstract: BACKGROUND & AIMS The α4β7 integrin is a validated target in inflammatory bowel disease. This randomized, phase 2b, placebo-controlled, double-blind study evaluated the efficacy and safety of the anti-α4β7 antibody abrilumab in patients with moderate-to-severe… read more here.

Keywords: response; severe ulcerative; ulcerative colitis; placebo ... See more keywords

Management of acute severe ulcerative colitis in children.

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recommendations! Published in 2017 at "Seminars in pediatric surgery"

DOI: 10.1053/j.sempedsurg.2017.10.006

Abstract: The incidence of pediatric-onset ulcerative colitis (UC) is rising. Children often present with a more severe disease phenotype as compared to adults with over a third requiring hospitalization for the management of acute severe ulcerative… read more here.

Keywords: acute severe; severe ulcerative; management acute; colitis ... See more keywords

Positioning ustekinumab in moderate-to-severe ulcerative colitis: new kid on the block

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recommendations! Published in 2020 at "Expert Opinion on Biological Therapy"

DOI: 10.1080/14712598.2020.1727437

Abstract: ABSTRACT Introduction: Ulcerative colitis (UC) is a chronic relapsing disorder of the colonic tract. Dysregulated innate and adaptive immune pathways contribute to intestinal inflammation in IBD, and cytokines, including IL-12 and IL-23, play a key… read more here.

Keywords: positioning ustekinumab; ustekinumab moderate; severe ulcerative; ulcerative colitis ... See more keywords

P489 Rescue treatment with original versus biosimilar infliximab in biologic-naïve patients with moderate-severe Ulcerative Colitis and corticosteroid failure

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recommendations! Published in 2021 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjab076.612

Abstract: Infliximab is effective as rescue therapy in moderate-severe Ulcerative Colitis (UC). Subsequently, a biosimilar of infliximab has been approved for the same indications, as its effectiveness is considered similar to the original infliximab. Our aim… read more here.

Keywords: moderate severe; severe ulcerative; ulcerative colitis; infliximab ... See more keywords

P1024 The current role of Tofacitinib in acute severe ulcerative colitis in adult patients: A systematic review and pooled analysis

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.1154

Abstract: Despite rescue therapy, acute severe ulcerative colitis (ASUC) is associated with high colectomy rates, while treatment options remain limited. Tofacitinib, a rapidly acting Janus Kinase (JAK) inhibitor, could be an effective treatment option for managing… read more here.

Keywords: tofacitinib; acute severe; severe ulcerative; ulcerative colitis ... See more keywords

P0513 Comparative Evaluation of Clinical Scores for Predicting Response to Systemic Steroid Treatment in Hospitalized Adult Patients with Acute Severe Ulcerative Colitis: A Retrospective Study

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recommendations! Published in 2025 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjae190.0687

Abstract: Approximately 30% of hospitalized patients with acute severe ulcerative colitis (ASUC) may be refractory to systemic glucocorticoid (GC) therapy, administered orally or intravenously necessitating salvage therapy 1. Clinical tools predicting response to GC could allow… read more here.

Keywords: response; severe ulcerative; acute severe; ulcerative colitis ... See more keywords

P0593 High-dose Tofacitinib in Acute Severe Ulcerative Colitis: an option to avoid colectomy?

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recommendations! Published in 2025 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjae190.0767

Abstract: 30% of patients with ulcerative colitis (UC) develop an acute severe ulcerative colitis (ASUC), which involves risk of colectomy and has limited treatments despite the development of new drugs. 30% of ASUC do not respond… read more here.

Keywords: colectomy; response; acute severe; severe ulcerative ... See more keywords