Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00658-8
Abstract: Maternal diabetes constitutes an unfavorable intrauterine environment for offspring development. Although it is known that diabetes can cause brain alterations and increased risk for neurologic disorders, the relationship between neuroimmune activation, brain changes, and neurodevelopment… read more here.
Keywords: uncontrolled maternal; cellular survival; hippocampus; severe uncontrolled ... See more keywords
Multidisciplinary Care for Severe or Uncontrolled Chronic Upper Airway Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Current Allergy and Asthma Reports"
DOI: 10.1007/s11882-021-01004-z
Abstract: A multidisciplinary approach is regarded as the best practice for many chronic diseases, such as cancer and asthma, with well-documented value. There is also evidence that it may be beneficial to patients with chronic rhinosinusitis… read more here.
Keywords: uncontrolled chronic; multidisciplinary care; severe uncontrolled; care severe ... See more keywords
Eosinophilic Granulomatosis with Polyangiitis: clinical predictors of long-term asthma severity.
Sign Up to like & getrecommendations! Published in 2020 at "Chest"
DOI: 10.1016/j.chest.2019.11.045
Abstract: BACKGROUND The long-term clinical course of asthma in patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA) remains unclear. We aimed to characterize long-term asthma in EGPA and to identify baseline predictors of long-term asthma severity. METHODS… read more here.
Keywords: term; long term; severe uncontrolled; term asthma ... See more keywords
Differences between patients who achieved asthma control and those who remain uncontrolled after standardized severe asthma care strategy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Asthma"
DOI: 10.1080/02770903.2020.1852415
Abstract: Abstract Objective To assess clinical, functional, and inflammatory patterns of children and adolescents with severe uncontrolled asthma, and investigate the differences between patients who achieved asthma control and those who remain uncontrolled after standardized asthma… read more here.
Keywords: asthma control; patients achieved; achieved asthma; severe uncontrolled ... See more keywords
Cost-effectiveness of benralizumab versus mepolizumab and dupilumab in patients with severe uncontrolled eosinophilic asthma in Spain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2139718
Abstract: Abstract Objective To assess the cost-effectiveness of benralizumab (benra) vs. mepolizumab (mepo) and dupilumab (dupi) for the treatment of patients with severe uncontrolled asthma from the Spanish Health System perspective. Methods Exacerbations avoided, quality-adjusted life… read more here.
Keywords: effectiveness benralizumab; eosinophilic asthma; asthma; patients severe ... See more keywords
Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1672657
Abstract: ABSTRACT Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. TSLP exerts its effects by binding to a high affinity… read more here.
Keywords: therapy; severe uncontrolled; uncontrolled asthma; tezepelumab ... See more keywords
Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population
Sign Up to like & getrecommendations! Published in 2017 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210531
Abstract: Background Little is known about the prevalence of severe, uncontrolled eosinophilic asthma (SUEA) and associated costs. Aims We sought to determine the prevalence of SUEA and compare asthma-related healthcare resource use (HCRU) and associated costs… read more here.
Keywords: suea; severe uncontrolled; year; uncontrolled eosinophilic ... See more keywords
Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of PATHWAY and NAVIGATOR Studies.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202210-2005oc
Abstract: RATIONALE Tezepelumab reduced exacerbations in patients with severe, uncontrolled asthma across a range of baseline blood eosinophil counts (BECs) and fractional exhaled nitric oxide (FeNO) levels, and irrespective of allergy status, in the phase 2b… read more here.
Keywords: severe uncontrolled; uncontrolled asthma; pooled analysis; pathway navigator ... See more keywords
Tezepelumab in the Treatment of Uncontrolled Severe Asthma
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Pharmacotherapy"
DOI: 10.1177/10600280221095540
Abstract: Objective: To review the pharmacology, efficacy, and safety of subcutaneous tezepelumab in the treatment of severe uncontrolled asthma. Data Sources: The PubMed database and ClinicalTrials.gov were searched using the following terms: tezepelumab, Tezspire, AMG157, and… read more here.
Keywords: pharmacology; tezepelumab treatment; asthma; severe uncontrolled ... See more keywords
Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asthma and Allergy"
DOI: 10.2147/jaa.s196200
Abstract: Background Asthma and bronchiectasis are different conditions that frequently coexist. The prevalence of bronchiectasis rises considerably in subjects with severe asthma (25%–51%). Objective We evaluated the clinical and biological efficacy of mepolizumab on our pilot… read more here.
Keywords: asthma bronchiectasis; uncontrolled asthma; severe uncontrolled; bronchiectasis ... See more keywords
Tezepelumab for Patients with Severe Uncontrolled Asthma: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma and Allergy"
DOI: 10.2147/jaa.s378062
Abstract: Abstract Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. It was approved by the United States Federal Drug Administration (US FDA) as an… read more here.
Keywords: tezepelumab; asthma; patients severe; analysis ... See more keywords