EEG-Guided Titration of Sevoflurane and Pediatric Anesthesia Emergence Delirium: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2025.0517
Abstract: Importance Pediatric anesthesia emergence delirium (PAED) is a common complication of general anesthesia and has unknown etiology. Exposure to volatile anesthetics may contribute to PAED, and excessive exposure may occur frequently during routine pediatric anesthesia.… read more here.
Keywords: sevoflurane; group; eeg guided; anesthesia ... See more keywords
Overexpression of Nfs1 Cysteine Desulphurase Relieves Sevoflurane‐Induced Neurotoxicity and Cognitive Dysfunction in Neonatal Mice Via Suppressing Oxidative Stress and Ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70051
Abstract: Clinical evidence suggests that multiple exposures to sevoflurane in young people may be detrimental to cognitive development. Iron accumulation in the hippocampus is associated with sevoflurane‐induced neurotoxicity and cognitive deficits. The cysteine desulphurase, Nfs1, the… read more here.
Keywords: oxidative stress; sevoflurane induced; sevoflurane; ferroptosis ... See more keywords
Long‐term sevoflurane exposure reduces the differentiation potential and hypoxia tolerance potential of neural stem cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10150
Abstract: To investigate the effect of prolonged sevoflurane (SEV) exposure on differentiation potential and hypoxia tolerance of neural stem cells (NSCs). read more here.
Keywords: neural stem; sevoflurane; differentiation potential; stem cells ... See more keywords
Sevoflurane neurotoxicity in neonatal rats is related to an increase in the GABAAR α1/GABAAR α2 ratio
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24118
Abstract: Exposure of neonatal rat to sevoflurane leads to neurodegeneration and deficits of spatial learning and memory in adulthood. However, the underlying mechanisms remain unclear. The type A γ‐aminobutyric acid receptor (GABAAR) is a target receptor… read more here.
Keywords: gabaar gabaar; exposure; expression; gabaar ... See more keywords
Environmental and biological measurements of isoflurane and sevoflurane in operating room personnel
Sign Up to like & getrecommendations! Published in 2017 at "International Archives of Occupational and Environmental Health"
DOI: 10.1007/s00420-017-1287-y
Abstract: PurposeThe present study aimed to compare the concentration of isoflurane and sevoflurane in the individual’s breathing zone and ambient air of operating rooms (ORs), to investigate the correlation between breathing zone levels and urinary concentrations,… read more here.
Keywords: isoflurane sevoflurane; concentration isoflurane; air; sevoflurane ... See more keywords
Sevoflurane in patients at risk of ventricular dysrhythmias
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Anesthesia"
DOI: 10.1007/s00540-017-2346-y
Abstract: 1. Terao Y, Higashijima U, Toyoda T, Ichinomiya T, Fukusaki M, Hara T. The effects of intravenous anesthetics on QT interval during anesthetic induction with sevoflurane. J Anesth. 2016;30:929–34. 2. Li J, Correa AM. Kinetic… read more here.
Keywords: sevoflurane patients; ventricular dysrhythmias; risk ventricular; patients risk ... See more keywords
Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Anesthesia"
DOI: 10.1007/s00540-018-2545-1
Abstract: BackgroundEpidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. Sevoflurane is widely used in pediatric anesthetic practice because of its rapid induction… read more here.
Keywords: cell cycle; sevoflurane induced; dex; sevoflurane ... See more keywords
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09601-4
Abstract: Clinical surgical practices have found that children who undergo multiple anesthesia may have an increased risk of deficiencies in cognition and fine motor control. Here, we report that YT521-B homology domain family 1 (YTHDF1), a… read more here.
Keywords: anesthesia; mrna translation; motor; fine motor ... See more keywords
RIPK1/RIPK3-Mediated Necroptosis is Involved in Sevoflurane-Induced Neonatal Neurotoxicity in the Rat Hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01098-z
Abstract: Recent studies have shown that exposure to sevoflurane in developing brains causes neuronal apoptosis and cognitive dysfunction. "Necroptosis" is a novel pathway of necrosis. We introduced the caspase-specific inhibitor Z-VAD in addition to the receptor-interacting… read more here.
Keywords: sevoflurane induced; necroptosis; ripk1 ripk3; sevoflurane ... See more keywords
A pharmacodynamic model of tidal volume and inspiratory sevoflurane concentration in children during spontaneous breathing
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-020-09729-6
Abstract: Purpose High concentrations of sevoflurane causes respiratory depression, mainly due to the decrease in tidal volume (TV) during spontaneous ventilation. The purpose of this study was to identify clinical variables that affect the relationship between… read more here.
Keywords: sevoflurane concentration; tidal volume; model; concentration ... See more keywords
Effect of Sevoflurane Anesthesia on Brain Is Mediated by lncRNA HOTAIR
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1029-y
Abstract: Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using inhaled anesthetics like sevoflurane,… read more here.
Keywords: sevoflurane anesthesia; hotair; cognitive dysfunction; brain ... See more keywords