Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.01.022
Abstract: Advancements in fetal intervention procedures have led to increases in the number of pregnant women undergoing general anesthesia during the second trimester-a period characterized by extensive proliferation of fetal neural stem cells (NSCs). However, few… read more here.
Keywords: sevoflurane exposure; group; proliferation; mid gestational ... See more keywords
Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00620
Abstract: The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but the specific effects and mechanism remain poorly understood. Pyroptosis caused by the activation of the NLRP3 inflammasome is pivotal… read more here.
Keywords: sevoflurane exposure; sevoflurane; asc inflammasome; sevoflurane induced ... See more keywords
Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15874
Abstract: Sevoflurane is a widely used general anaesthetic in paediatric patients. Although repeated sevoflurane exposure is known to cause neurodevelopmental disorders in children, the mechanism of this neurotoxicity remains largely unknown. Herein, we investigated the role… read more here.
Keywords: repeated sevoflurane; glutamate transporter; sevoflurane exposure; sevoflurane ... See more keywords
Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells International"
DOI: 10.1155/2017/6158468
Abstract: Maternal sevoflurane exposure during pregnancy is associated with increased risk for behavioral deficits in offspring. Several studies indicated that neurogenesis abnormality may be responsible for the sevoflurane-induced neurotoxicity, but the concrete impact of sevoflurane on… read more here.
Keywords: abnormal development; maternal sevoflurane; sevoflurane exposure; sevoflurane ... See more keywords
Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stress via activation of the inositol 1, 4, 5-trisphosphate receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.990679
Abstract: The role of the inositol 1, 4, 5-trisphosphate receptor (IP3R) in hippocampal neuronal apoptosis and cognitive dysfunction induced by sevoflurane is currently unclear. Therefore, in this study, we investigated the role of the IP3R in… read more here.
Keywords: cognitive dysfunction; neuronal apoptosis; sevoflurane exposure; sevoflurane ... See more keywords
Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1006175
Abstract: Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment. The PI3K/AKT/mTOR pathway plays an important… read more here.
Keywords: pi3k akt; sevoflurane exposure; dendritic spines; sevoflurane ... See more keywords
Blood–brain barrier disruption caused by neonatal sevoflurane-induced depends on exposure time and is reversible in mice
Sign Up to like & getrecommendations! Published in 2019 at "Korean Journal of Anesthesiology"
DOI: 10.4097/kja.d.19.00029
Abstract: es neuronal apoptosis and results in learning deficits in rodents [1,2]. We showed that exposure to 2% sevoflurane for 6 h resulted in blood–brain barrier (BBB) disruption in the hippocampus of postnatal day 6 (POD6)… read more here.
Keywords: disruption; sevoflurane exposure; time; mice ... See more keywords