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   Articles with "sevoflurane induced" as a keyword



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Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus

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recommendations! Published in 2018 at "Journal of Anesthesia"

DOI: 10.1007/s00540-018-2545-1

Abstract: BackgroundEpidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. Sevoflurane is widely used in pediatric anesthetic practice because of its rapid induction… read more here.

Keywords: cell cycle; sevoflurane induced; dex; sevoflurane ... See more keywords
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RIPK1/RIPK3-Mediated Necroptosis is Involved in Sevoflurane-Induced Neonatal Neurotoxicity in the Rat Hippocampus.

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recommendations! Published in 2021 at "Cellular and molecular neurobiology"

DOI: 10.1007/s10571-021-01098-z

Abstract: Recent studies have shown that exposure to sevoflurane in developing brains causes neuronal apoptosis and cognitive dysfunction. "Necroptosis" is a novel pathway of necrosis. We introduced the caspase-specific inhibitor Z-VAD in addition to the receptor-interacting… read more here.

Keywords: sevoflurane induced; necroptosis; ripk1 ripk3; sevoflurane ... See more keywords
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Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice

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recommendations! Published in 2019 at "Journal of Molecular Neuroscience"

DOI: 10.1007/s12031-019-01303-1

Abstract: Sevoflurane is a widely used anesthetic. A series of recent studies have shown that exposure to sevoflurane at an early stage is a risk factor for the development of learning and memory dysfunction. Euxanthone is… read more here.

Keywords: euxanthone; induced neurotoxicity; expression; sevoflurane induced ... See more keywords
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Metformin attenuates sevoflurane-induced neurocognitive impairment through AMPK-ULK1-dependent autophagy in aged mice

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recommendations! Published in 2020 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2020.01.018

Abstract: Neurocognitive impairment risk increases with age and is further enhanced after anaesthesia, resulting in significant long-term morbidity and an overall reduced quality of life. Metformin activates autophagy, a key process that protects against cognitive dysfunction.… read more here.

Keywords: induced neurocognitive; ampk; impairment; autophagy ... See more keywords
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Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway.

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recommendations! Published in 2019 at "Life sciences"

DOI: 10.1016/j.lfs.2019.117151

Abstract: AIMS Anaesthesia-related neurotoxicity in the developing brain is a controversial issue that has recently attracted much attention. Hemin plays a protective role in hypoxic and ischemic brain damage; however, its effects on sevoflurane-induced neurotoxicity remain… read more here.

Keywords: induced neurotoxicity; neurotoxicity; via phosphoinositide; sevoflurane induced ... See more keywords
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GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.

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recommendations! Published in 2022 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.1c00830

Abstract: Ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) is a member of proton-sensing G-protein-coupled receptors, involved in cardiovascular physiology, tumor biology, and asthma, and exerts a neuroprotective effect against brain ischemia. The effects… read more here.

Keywords: damage myelination; nerve damage; gpr68; sevoflurane induced ... See more keywords
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Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation.

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recommendations! Published in 2023 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.2c00620

Abstract: The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but the specific effects and mechanism remain poorly understood. Pyroptosis caused by the activation of the NLRP3 inflammasome is pivotal… read more here.

Keywords: sevoflurane exposure; sevoflurane; asc inflammasome; sevoflurane induced ... See more keywords
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Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1

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recommendations! Published in 2022 at "Toxicology Mechanisms and Methods"

DOI: 10.1080/15376516.2022.2128705

Abstract: Abstract To confirm the regulation of miR-204-5p on VCAM1 and its effect on sevoflurane-induced brain injury in neonatal rats. We adopted the sevoflurane-induced brain injury model, and the double luciferase reporter gene assay was applied… read more here.

Keywords: mir 204; brain injury; induced brain; sevoflurane induced ... See more keywords
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Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway.

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recommendations! Published in 2019 at "Behavioural Pharmacology"

DOI: 10.1097/fbp.0000000000000507

Abstract: Chronic inflammation plays an important role in the mechanisms underpinning the development of anesthesia-induced cognitive dysfunction. However, less is known about how anesthesia causes inflammation. One possibility is that the inflammation is related to alteration… read more here.

Keywords: anti inflammatory; cholinergic anti; sevoflurane induced; inflammatory pathway ... See more keywords

MicroRNA‐27a‐3p suppression of peroxisome proliferator‐activated receptor‐γ contributes to cognitive impairments resulting from sevoflurane treatment

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recommendations! Published in 2017 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14208

Abstract: Sevoflurane is the most widely used anaesthetic administered by inhalation. Exposure to sevoflurane in neonatal mice can induce learning deficits and abnormal social behaviours. MicroRNA (miR)‐27a‐3p, a short, non‐coding RNA that functions as a tumour… read more here.

Keywords: ppar; peroxisome proliferator; mir 27a; expression ... See more keywords
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Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4

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recommendations! Published in 2023 at "Mediators of Inflammation"

DOI: 10.1155/2023/7750134

Abstract: Objective To explore the molecular mechanism of sevoflurane-induced neurotoxicity and to determine whether lncRNA HOXA11-AS affects sevoflurane-induced neuronal apoptosis and inflammation by regulating miR-98-5p/EphA4. Methods Morris water maze (MWM) test was used to detect the… read more here.

Keywords: neuronal apoptosis; apoptosis; sevoflurane induced; mir epha4 ... See more keywords