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   Articles with "sf3b1 mutation" as a keyword



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Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes

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recommendations! Published in 2021 at "Cancer"

DOI: 10.1002/cncr.33745

Abstract: SF3B1 mutations (SF3B1mut) in myelodysplastic syndromes (MDS) frequently involve codon K700E and have a favorable prognosis. The prognostic effect of non‐K700E SF3B1mut is uncertain. read more here.

Keywords: myelodysplastic syndromes; mutation involving; sf3b1 mutation; independently predicts ... See more keywords

Predicting survival in patients with myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis

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recommendations! Published in 2024 at "Leukemia"

DOI: 10.1038/s41375-024-02262-2

Abstract: We investigated data from 180 consecutive patients with myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis (MDS/MPN-SF3B1-T) who were diagnosed according to the 2022 World Health Organization (WHO) classification of myeloid neoplasms to identify covariates associated… read more here.

Keywords: patients myelodysplastic; myeloproliferative neoplasms; sf3b1 mutation; mutation ... See more keywords

101 SF3B1 Mutation and Overlapping Features of MDS/MPN-SF3B1-T and CLL: A Diagnostic Challenge

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recommendations! Published in 2025 at "American Journal of Clinical Pathology"

DOI: 10.1093/ajcp/aqaf121.231

Abstract: SF3B1 mutations are associated with several hematologic malignancies, including chronic lymphocytic leukemia (CLL) and myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis (MDS/MPN-SF3B1-T). CLL cases with SF3B1 mutations often show 11q deletions, while MDS/MPN-SF3B1-T is typically… read more here.

Keywords: cll; sf3b1; mds mpn; sf3b1 mutation ... See more keywords

Mitochondrial Transcriptional-Translational Conflict Contributes to Defective Erythropoiesis and Disease Progression in Splicing Factor Mutant Myelodysplastic Syndromes

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-204428

Abstract: Myelodysplastic syndromes (MDS) are myeloid malignancies derived from hematopoietic stem progenitor cells (HSPCs), characterized by cytopenia, dysplastic and ineffective hematopoiesis and a high risk of developing acute myeloid leukemia. SF3B1 is the most frequently mutated… read more here.

Keywords: sf3b1 k700e; sf3b1; mds; translation ... See more keywords

A Novel Prognostic Scoring Model for Myelodysplastic Syndrome Patients With SF3B1 Mutation

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.905490

Abstract: The outcomes of myelodysplastic syndrome (MDS) patients with SF3B1 mutation, despite identified as a favorable prognostic biomarker, are variable. To comprehend the heterogeneity in clinical characteristics and outcomes, we reviewed 140 MDS patients with SF3B1… read more here.

Keywords: prognostic scoring; sf3b1 mutation; model; patients sf3b1 ... See more keywords