Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal.
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DOI: 10.1016/j.exphem.2018.11.001
Abstract: Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are clonal stem cell disorders, primarily affecting patients over 65 years of age. Mapping of the MDS and MDS/MPN genome identified recurrent heterozygous mutations in the RNA… read more here.
Keywords: murine models; modeling human; human rna; sf3b1 srsf2 ... See more keywords