Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
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DOI: 10.1371/journal.pone.0175523
Abstract: More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with… read more here.
Keywords: transcription; sf3b1k700e mutant; erythroid differentiation; splicing transcription ... See more keywords