Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106127
Abstract: Preeclampsia is a severe complication of pregnancy characterized by variable degrees of placental malperfusion. A growing body of evidence indicates that soluble endoglin and soluble fms-like tyrosine kinase-1 (sFlt-1) play important pathophysiological roles in preeclampsia,… read more here.
Keywords: angiogenesis; endothelial dysfunction; procyanidin; preeclampsia ... See more keywords
Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms.
Sign Up to like & getrecommendations! Published in 2019 at "Placenta"
DOI: 10.1016/j.placenta.2019.08.083
Abstract: We performed an inter-assay comparison among three immunoassay platforms for midpregnancy testing of sFlt-1, PlGF and the sFlt-1/PlGF ratio, which are established markers for pre-eclampsia. Maternal blood was collected 19-22 weeks' gestation. Raw data values… read more here.
Keywords: sflt; immunoassay platforms; inter assay; assay comparison ... See more keywords
17-Hydroxyprogesterone caproate improves hypertension and renal endothelin-1 in response to sFlt-1 induced hypertension in pregnant rats.
Sign Up to like & getrecommendations! Published in 2020 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2020.09.002
Abstract: Preeclampsia (PE) is characterized by new onset hypertension in association with elevated soluble fms-like tyrosine kinase-1 (sFlt-1) and preproendothelin-1 (PPET-1) levels. Currently there is no effective treatment for PE except for early delivery of the… read more here.
Keywords: sflt; response; pregnant rats; hydroxyprogesterone caproate ... See more keywords
Vitamin D Supplementation Prevents Placental Ischemia Induced Endothelial Dysfunction by Downregulating Placental Soluble FMS-Like Tyrosine Kinase-1.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3817
Abstract: Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought… read more here.
Keywords: rupp; vitamin supplementation; sflt; endothelial dysfunction ... See more keywords
Association of sFlt-1 and C-reactive protein with outcomes in severe preeclampsia: A cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029059
Abstract: ABSTRACT To determine the association between soluble FMS-like tyrosine kinase-1 (sFlt-1) and high-sensitivity C-reactive protein (hs-CRP) with maternal and perinatal outcomes in patients with preeclampsia (PE) with severe features.A cohort study was conducted on 100… read more here.
Keywords: reactive protein; severe features; sflt; cohort study ... See more keywords
VEGF (Vascular Endothelial Growth Factor) Functionalized Magnetic Beads in a Microfluidic Device to Improve the Angiogenic Balance in Preeclampsia.
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.12380
Abstract: Preeclampsia is a hypertensive pregnancy disease associated with a massive increase in sFlt-1 (soluble form of the vascular endothelial growth factor 1) in the maternal circulation, responsible for angiogenic imbalance and endothelial dysfunction. Pilot studies… read more here.
Keywords: growth factor; vascular endothelial; magnetic beads; sflt ... See more keywords
Total Versus Free Placental Growth Factor Levels in the Pathogenesis of Preeclampsia
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.15338
Abstract: Elevated circulating sFLT-1 (soluble fms-like tyrosine kinase) and low levels of its ligand, PlGF (placental growth factor), are key characteristics of preeclampsia. However, it is unclear if the low levels of plasma PlGF noted during… read more here.
Keywords: plgf; preeclampsia; versus; placental growth ... See more keywords
Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240473
Abstract: Background Post-term pregnancies have increased risks for adverse fetal and maternal outcomes. Maternal concentrations of the placenta-associated proteins placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) have been identified as predictors for preeclampsia… read more here.
Keywords: sflt; term pregnancies; term; plgf ... See more keywords
The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice
Sign Up to like & getrecommendations! Published in 2017 at "Aging and Disease"
DOI: 10.14336/ad.2016.0920
Abstract: The mechanism by which angiogenesis declines with aging is not fully understood. Soluble vascular endothelial growth factor receptor 1 (VEGFR1) form (sFlt1) contributes to endothelial dysfunction in pathological conditions. However, the roles of sFlt1 in… read more here.
Keywords: sflt; soluble vegf; vegf receptor; neovascularization ... See more keywords
Placenta growth factor and sFlt-1 as biomarkers in ischemic heart disease and heart failure: a review.
Sign Up to like & getrecommendations! Published in 2019 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2018-0492
Abstract: Coronary heart disease (CHD) and heart failure (HF) produce significant morbidity/mortality but identifying new biomarkers could help in the management of each. In this article, we summarize the molecular regulation and biomarker potential of PIGF and… read more here.
Keywords: sflt; heart disease; heart; heart failure ... See more keywords
Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia.
Sign Up to like & getrecommendations! Published in 2021 at "Nanomedicine"
DOI: 10.2217/nnm-2021-0180
Abstract: Background: Overexpression of sFlt-1 or modulation of FKBPL, key antiangiogenic proteins, are important in the pathogenesis of preeclampsia. Methods: A newly developed nonviral gene-delivery system, RALA, capable of overexpressing sFlt-1 (e15a isoform) was delivered in… read more here.
Keywords: rala; sflt; preeclampsia; gene delivery ... See more keywords