Modulating circulating sFlt1 in an animal model of preeclampsia using PAMAM nanoparticles for siRNA delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2017.07.360
Abstract: INTRODUCTION Excessive circulating sFlt1 plays a major role in the pathogenesis of preeclampsia (PE). Using RNAi to silence sFlt1 may be a therapy for treating PE. Because of the rapid degradation of siRNA, gene therapy… read more here.
Keywords: sflt1 pamam; sflt1; model; sirna sflt1 ... See more keywords
A novel RNA interference approach to targeting sFLT1 in pre-eclampsia
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-018-0093-4
Abstract: Nature reviews | Nephrology abnormally high levels of soluble FLt1 (sFLt1; also known as sveGFr1) have a key role in the pathogenesis of pre-eclampsia. Now, ananth Karumanchi and colleagues have developed an rNa interference (rNai)… read more here.
Keywords: sflt1; nephrology; pre; pre eclampsia ... See more keywords
Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81785-5
Abstract: Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE… read more here.
Keywords: sflt1; sflt1 plgf; gdm; relative ctrl ... See more keywords
Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental Preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3024032
Abstract: The pregnancy disorder preeclampsia (PE) is characterized by maternal hypertension, increased level of circulating antiangiogenic soluble fms-like tyrosine kinase-1 (sFLT1), and reduced placental perfusion, leading to foetal growth restriction (FGR) and preterm birth. All these… read more here.
Keywords: brain development; overexpression; brain; foetal brain ... See more keywords
Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321228
Abstract: Background: Preeclampsia is a syndrome of high blood pressure (BP) with end organ damage in late pregnancy that is associated with high circulating soluble VEGF receptor (sFlt1 [soluble Fms-like tyrosine kinase 1]). Women exposed to… read more here.
Keywords: hypertension; preeclampsia; sflt1; pregnancy ... See more keywords
Circulating levels of angiogenic factors and their association with preeclampsia among pregnant women at Mulago National Referral Hospital in Uganda
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0251227
Abstract: Preeclampsia (PE) is a major cause of maternal and new-born morbidity and mortality. Angiogenic factors contribute a major role in the vascular dysfunction associated with PE. We investigated the circulating levels of vascular endothelial growth… read more here.
Keywords: sflt1; plgf; pregnant women; among pregnant ... See more keywords
The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179660
Abstract: (1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to peritubular… read more here.
Keywords: soluble fms; like tyrosine; sflt1; tyrosine kinase ... See more keywords