Prognostic potential of KLOTHO and SFRP1 promoter methylation in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Genetics"
DOI: 10.1007/s13353-017-0404-7
Abstract: Hypermethylation in the CpG island promoter regions of tumor suppressors is known to play a significant role in the development of HNSCC and the detection of which can aid the classification and prognosis of HNSCC.… read more here.
Keywords: potential klotho; methylation; prognostic potential; promoter ... See more keywords
A specific haplotype in potential miRNAs binding sites of secreted frizzled-related protein 1 (SFRP1) is associated with BMD variation in osteoporosis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.061
Abstract: PURPOSE Osteoporosis is an important multifactorial disease which is largely influenced by Wnt signaling pathway. Considering regulatory single nucleotide polymorphisms in Wnt signaling pathway may pave the road of understanding the genetic basis of predisposition… read more here.
Keywords: bmd variation; spine bmd; sfrp1; lumbar spine ... See more keywords
The WNT Antagonist SFRP1 - a Key Regulator of Periodontal Mineral Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells and development"
DOI: 10.1089/scd.2019.0124
Abstract: The function of mammalian periodontal tissues depends on the presence of a non-mineralized periodontal ligament juxtaposed in between mineralized tooth anchorage tissues alveolar bone and root cementum. In the present study we have hypothesized that… read more here.
Keywords: wnt antagonist; antagonist sfrp1; mineral homeostasis; alveolar bone ... See more keywords
Sfrp1 Modulates Cell‐signaling Events Underlying Telencephalic Patterning, Growth and Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhy013
Abstract: &NA; The mammalian dorsal telencephalic neuroepithelium develops—from medial to lateral—into the choroid plaque, cortical hem, hippocampal primordium and isocortex under the influence of Bmp, Wnt and Notch signaling. Correct telencephalic development requires a tight coordination… read more here.
Keywords: wnt notch; wnt; medio lateral; sfrp1 ... See more keywords
BMP-AKT-GSK3β signalling restores hair follicle stem cells decrease associated with loss of Sfrp1.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac041
Abstract: Wnt signaling plays a pivotal role in regulating activation, proliferation, stem cell renewal and differentiation of hair follicle stem cells (HFSCs). Secreted frizzled related protein-1 (Sfrp1), a Wnt antagonist is up regulated in the HFSCs;… read more here.
Keywords: hair follicle; sfrp1; akt gsk3; bmp akt ... See more keywords
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01333-5
Abstract: Background Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones that results from… read more here.
Keywords: tmprss2 erg; sfrp1 protein; expression; cancer ... See more keywords
Sfrp1 attenuates TAC-induced cardiac dysfunction by inhibiting Wnt signaling pathway- mediated myocardial apoptosis in mice
Sign Up to like & getrecommendations! Published in 2018 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-018-0832-3
Abstract: BackgroundHemodynamic overload causes cardiac hypertrophy leading to heart failure. Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related protein 1 (Sfrp1) is a suppressor of Wnt signaling activation. The aim of the… read more here.
Keywords: vector; wnt signaling; induced cardiac; signaling pathway ... See more keywords
Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1
Sign Up to like & getrecommendations! Published in 2020 at "Brain Sciences"
DOI: 10.3390/brainsci10020122
Abstract: Amyloid β (Aβ) peptides generated via sequential β- and γ-secretase processing of the amyloid precursor protein (APP) are major etiopathological agents of Alzheimer’s disease (AD). However, an initial APP cleavage by an α-secretase, such as… read more here.
Keywords: enhancing secretase; alzheimer disease; secretase processing; sfrp1 ... See more keywords
Identification and Validation of Potentially Clinically Relevant CpG Regions within the Class 2 Tumor Suppressor Gene SFRP1 in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030683
Abstract: Simple Summary Pancreatic cancer is one of the deadliest cancer entities with five-year survival rates of less than 11%. Besides standardly used surgical therapy, available chemotherapies are increasingly used to prolong overall survival. Promoter hypermethylation… read more here.
Keywords: gene; pancreatic cancer; sfrp1; tumor ... See more keywords
Epigenetic network of EZH2/SFRP1/Wnt in the epithelial-mesenchymal transition of laryngeal carcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_211208n1749
Abstract: Enhancer of Zeste Homologue 2 (EZH2) as a histone methyltransferase epigenetically regulates laryngeal carcinoma (LGC) progression. The present study sought to explore the role and mechanism of EZH2 in the epithelial-mesenchymal transition (EMT) of LGC… read more here.
Keywords: h3k27me3; ezh2; lgc; sfrp1 ... See more keywords