Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2
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DOI: 10.1186/s12915-020-00883-4
Abstract: Background Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast… read more here.
Keywords: wnt signaling; trophoblast differentiation; sfrp1 sfrp5; differentiation ... See more keywords