DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis
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DOI: 10.1007/s00109-017-1538-0
Abstract: Renal fibrosis is the most common outcome of chronic kidney disease (CKD), while the pathogenesis of renal fibrosis is not fully understood. In this study, we first showed that the progress of renal fibrosis was… read more here.
Keywords: sfrp5; fibrosis; indoxyl sulfate; renal fibrosis ... See more keywords
Secreted frizzled-related protein 5 promotes angiogenesis of human umbilical vein endothelial cells and alleviates myocardial injury in diabetic mice with myocardial infarction by inhibiting Wnt5a/JNK signaling
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DOI: 10.1080/21655979.2022.2070964
Abstract: ABSTRACT The purpose of this study is to investigate whether secreted frizzled-related protein 5 (SFRP5) affects the proliferation, migration and angiogenesis of human umbilical vein endothelial cells (HUVECs) induced by high glucose (HG). HUVECs were… read more here.
Keywords: wnt5a jnk; sfrp5; jnk; mice ... See more keywords
Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-021-02260-5
Abstract: Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate whether SFRP5 could protect chondrocytes against… read more here.
Keywords: sfrp5; wnt5a jnk; inflammation apoptosis; overexpression ... See more keywords
Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity
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DOI: 10.3390/ijms22136895
Abstract: Secreted frizzled-related protein 5 (SFRP5), an antagonist of the noncanonical WNT pathway, has a controversial role in liver disease. The aim of this study was to analyze the role of SFRP5 and the noncanonical WNT… read more here.
Keywords: sfrp5; frizzled related; related protein; liver disease ... See more keywords
Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity
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DOI: 10.3390/ijms23179871
Abstract: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipocytokine secreted by adipocytes that seems to be linked with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the role of the SFRP5-wingless-MMTV integration site family… read more here.
Keywords: sfrp5; secreted frizzled; expression; mrna expression ... See more keywords