Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC
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DOI: 10.1038/pr.2018.30
Abstract: BackgroundMutations in the NK2 homeobox 1 (NKX2-1) gene are associated with lung disease in infants and children. We hypothesize that disruption of normal surfactant gene expression with these mutations contributes to the respiratory phenotypes observed.MethodsTo… read more here.
Keywords: gene; sftpb sftpc; expression; mutations thyroid ... See more keywords