A novel three‐plasmid packaging system for chimeric SFV/SIN VRPs derived from Semliki Forest virus and Sindbis virus as a candidate gene delivery vector
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29376
Abstract: Semliki Forest virus (SFV) viral replicon particles (VRPs) have been frequently used in various animal models and clinical trials. Chimeric replicon particles offer different advantages because of their unique biological properties. We here constructed a… read more here.
Keywords: chimeric vrps; sfv; virus; gene ... See more keywords
VLDLR mediates Semliki Forest virus neuroinvasion through the blood-cerebrospinal fluid barrier
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-55493-3
Abstract: Semliki Forest virus (SFV) is a neuropathogenic alphavirus which is of interest both as a model neurotropic alphavirus and as an oncolytic virus with proven potency in preclinical cancer models. In laboratory mice, peripherally administered… read more here.
Keywords: blood cerebrospinal; forest virus; sfv; barrier ... See more keywords
Full spectrum endoscopy (FUSE) versus standard forward-viewing endoscope (SFV) in a high-risk population
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2017.1363278
Abstract: Abstract Objectives: To investigate the diagnostic performance of Full Spectrum Endoscopy (FUSE) compared to a conventional standard forward-viewing endoscope (SFV). The primary outcome was adenoma detection rate (ADR) and mean adenoma detection. Secondary outcome was… read more here.
Keywords: detection; endoscopy fuse; sfv; spectrum endoscopy ... See more keywords
STLV-1 co-infection is correlated with an increased SFV proviral load in the peripheral blood of SFV/STLV-1 naturally infected non-human primates
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006812
Abstract: Simian T-Leukemia Virus type 1 and Simian Foamy Virus infect non-human primates. While STLV-1, as HTLV-1, causes Adult T-cell Leukemia/lymphoma, SFV infection is asymptomatic. Both retroviruses can be transmitted from NHPs to humans through bites… read more here.
Keywords: stlv infection; non human; sfv; infection ... See more keywords
A non-invasive specimen collection method and a novel simian foamy virus (SFV) DNA quantification assay in New World primates reveal aspects of tissue tropism and improved SFV detection
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184251
Abstract: Simian foamy viruses (SFVs) co-evolved with a wide range of Old World and New World primates (OWPs and NWPs, respectively) and occasionally transmit to humans. Previous studies of OWPs showed that the predominant site of… read more here.
Keywords: nwp sfv; simian foamy; detection; sfv ... See more keywords
Potent neutralizing antibodies in humans infected with zoonotic simian foamy viruses target conserved epitopes located in the dimorphic domain of the surface envelope protein
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007293
Abstract: Human diseases of zoonotic origin are a major public health problem. Simian foamy viruses (SFVs) are complex retroviruses which are currently spilling over to humans. Replication-competent SFVs persist over the lifetime of their human hosts,… read more here.
Keywords: simian foamy; sfv; neutralizing antibodies; foamy viruses ... See more keywords
Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010470
Abstract: Zoonotic simian foamy viruses (SFV) establish lifelong infection in their human hosts. Despite repeated transmission of SFV from nonhuman primates to humans, neither transmission between human hosts nor severe clinical manifestations have been reported. We… read more here.
Keywords: plasma antibodies; cell; surface; transmission ... See more keywords
Structural insights into Semiliki forest virus receptor binding modes indicate novel mechanism of virus endocytosis
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012770
Abstract: The Very Low-Density Lipoprotein Receptor (VLDLR) is an entry receptor for the prototypic alphavirus Semliki Forest Virus (SFV). However, the precise mechanisms underlying the entry of SFV into cells mediated by VLDLR remain unclear. In… read more here.
Keywords: receptor; forest virus; sfv; virus ... See more keywords