Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_100
Abstract: The burden of heart failure (HF) increases worldwide with an aging population, and there is a high unmet medical need in both, heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF).… read more here.
Keywords: sgc stimulators; heart; treatment; heart failure ... See more keywords
Ocular sebaceous gland carcinoma: an update of the literature
Sign Up to like & getrecommendations! Published in 2018 at "International Ophthalmology"
DOI: 10.1007/s10792-018-0925-z
Abstract: PurposeTo review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment.MethodsA PubMed search was carried out using the terms “Sebaceous Carcinoma”, “Meibomian Gland Carcinoma”, “Sebaceous Cell Carcinoma”, and… read more here.
Keywords: gland carcinoma; carcinoma; sebaceous gland; sgc ... See more keywords
Percutaneous removal of a knotted Swan–Ganz catheter
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Intervention and Therapeutics"
DOI: 10.1007/s12928-021-00822-2
Abstract: A 48-year-old man who had undergone aortic valve surgery 1 week previously became hemodynamically unstable in the intensive care unit. His physician decided to insert a Swan–Ganz catheter (SGC) (Edwards Lifesciences, Tokyo, Japan) without fluoroscopic… read more here.
Keywords: ganz catheter; swan ganz; knot; removal ... See more keywords
The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-0211-4
Abstract: Scirrhous gastric cancer (SGC) exhibits aggressiveness of the rapid infiltrating tumor cells with abundant fibroblasts. Experimental studies using SGC cell lines have obtained useful information about this cancer. Our literature search divulged a total of… read more here.
Keywords: scirrhous gastric; cell; cell lines; sgc ... See more keywords
Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0604-7
Abstract: Oral riociguat is a soluble guanylate cyclase (sGC) stimulator that targets the nitric oxide (NO)–sGC–cyclic guanosine monophosphate pathway with a dual mode of action: directly by stimulating sGC, and indirectly by increasing the sensitivity of… read more here.
Keywords: pharmacodynamic profile; profile riociguat; sgc; pharmacokinetic pharmacodynamic ... See more keywords
Targeting heme-oxidized soluble guanylate cyclase to promote osteoblast function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.12.004
Abstract: The enzyme soluble guanylate cyclase (sGC) plays an essential part in the nitric oxide (NO) signaling pathway by binding to the prosthetic heme group; thereby catalyzing the synthesis of cyclic guanosine monophosphate (cGMP)-dependent protein kinases.… read more here.
Keywords: osteoblast function; heme oxidized; soluble guanylate; guanylate cyclase ... See more keywords
Trans‐4‐methoxy‐&bgr;‐nitrostyrene relaxes rat thoracic aorta through a sGC‐dependent pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.05.007
Abstract: Abstract 1‐Nitro‐2‐phenylethene (NPe) induces a more potent vasorelaxant effect in rat aorta than its structural analog 1‐nitro‐2‐phenylethane, but mediated through a different mechanism, independent of soluble guanylate cyclase (sGC) stimulation. We hypothesized that introducing an… read more here.
Keywords: trans methoxy; bgr nitrostyrene; methoxy bgr; pathway ... See more keywords
Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.020
Abstract: Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in platelets. Red blood cells (RBCs) are known to produce NO under… read more here.
Keywords: soluble guanylate; guanylate cyclase; signaling pathway; sgc ... See more keywords
Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2016.08.022
Abstract: It is now well established that the NO-sGC-cGMP signal transduction system mediates many different physiological functions in almost every conceivable organ system; this has been best characterized in the cardiovascular system where NO-driven cGMP production… read more here.
Keywords: sgc modulators; anti fibrotic; fibrosis; evidence ... See more keywords
Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00052
Abstract: Soluble guanylate cyclase (sGC) is the primary nitric oxide (NO) receptor in higher eukaryotes, including humans. NO-dependent signaling via sGC is associated with important physiological effects in the vascular, pulmonary, and neurological systems, and sGC… read more here.
Keywords: soluble guanylate; coiled coil; guanylate cyclase; sgc ... See more keywords
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02154
Abstract: Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is a key regulator of body… read more here.
Keywords: soluble guanylate; guanylate cyclase; sgc; activator runcaciguat ... See more keywords