Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/circresaha.117.310705
Abstract: Rationale: Soluble guanylate cyclase (sGC) heme iron, in its oxidized state (Fe3+), is desensitized to NO and limits cGMP production needed for downstream activation of protein kinase G–dependent signaling and blood vessel dilation. Objective: Although… read more here.
Keywords: cytochrome reductase; heme iron; reductase; sgc heme ... See more keywords
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.129183
Abstract: Nitric oxide (NO) regulates blood pressure (BP) by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMC). We previously showed that sGC heme iron reduction (Fe3+… read more here.
Keywords: cyb5r3; smooth muscle; smc cyb5r3; sgc heme ... See more keywords