Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.10.010
Abstract: &NA; The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of &agr;4/&bgr;3 subunit‐containing extrasynaptic GABAARs, leading to a sustained increase… read more here.
Keywords: allo sge; sge 516; exposure; protein kinase ... See more keywords