SGK1, autophagy and cancer: an overview.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06836-6
Abstract: BACKGROUND The serum and glucocorticoid-induced kinase-1 (SGK1) belonging to the AGC protein kinase family phosphorylates serine and threonine residues of target proteins. It regulates numerous ion channels and transporters and promotes survival under cellular stress.… read more here.
Keywords: sgk1; autophagy cancer; biology; cancer ... See more keywords
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-020-00773-x
Abstract: Dexamethasone augments mitochondrial protein abundance. The translocase of the outer membrane (Tom) of mitochondria plays a major role in importing largely cytosolically synthesized proteins into mitochondria. We hypothesize that dexamethasone upregulates the Tom transport system,… read more here.
Keywords: dexamethasone; sgk1; tom70 mnsod; tom20 tom70 ... See more keywords
Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.165
Abstract: Aberrant expression of Serum-glucocorticoid kinase 1 (SGK1) contributes to the pathogenesis of multiple disorders, including diabetes, hypertension, obesity, fibrosis, and metabolic syndrome. SGK1 variant is expressed in the presence of insulin and several growth factors,… read more here.
Keywords: sgk1; glucocorticoid kinase; kinase; diabetic nephropathy ... See more keywords
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01601
Abstract: The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. Today, no oral disease-modifying… read more here.
Keywords: sgk1; highly potent; treatment; rational design ... See more keywords
Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.19
Abstract: Chromatin remodeling factor metastatic tumor protein 1 (MTA1), one of the most upregulated oncogene in human cancer, has an important role in gene expression, cell survival and promoting hypoxic response. Successful cancer progression is dependent… read more here.
Keywords: sgk1; sgk1 transcription; translocation; repression sgk1 ... See more keywords
Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2153841
Abstract: Abstract SGK1 is a serine/threonine kinase involved in several neurodegenerative-related pathways such as apoptosis, neuroinflammation, ionic channel regulation, and autophagy, among others. Despite its potential role as a pharmacological target against this kind of diseases,… read more here.
Keywords: identification new; new structural; sgk1 inhibitors; structural family ... See more keywords
High-fat diet–induced activation of SGK1 promotes Alzheimer’s disease–associated tau pathology
Sign Up to like & getrecommendations! Published in 2021 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddab115
Abstract: Abstract Type 2 diabetes mellitus (T2DM) has long been considered a risk factor for Alzheimer’s disease (AD). However, the molecular links between T2DM and AD remain obscure. Here, we reported that serum-/glucocorticoid-regulated kinase 1 (SGK1)… read more here.
Keywords: sgk1; alzheimer disease; tau pathology; pathology ... See more keywords
Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine non-responsive CSU.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad025
Abstract: Inflammation centered on non-IgE-mediated mast cell activation characterizes chronic spontaneous urticaria (CSU) resistant to non-sedating H1-antihistamines (nsAH). We recently uncovered a strong positive association between inflammation and the fecal Escherichia. To further explore the actions… read more here.
Keywords: inflammation; mast; btdna; bacterial dna ... See more keywords
Lipid droplets and autophagosomes together with chaperones fine‐tune expression of SGK1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17300
Abstract: Serum‐glucocorticoid‐induced kinase‐1 (SGK1) regulates ion homeostasis and promotes survival under stress conditions. The expression of SGK1 is under transcriptional and post‐translational regulations that are frequently altered in cancer and immune disorders. We report that an… read more here.
Keywords: lipid droplets; sgk1 expression; droplets autophagosomes; expression ... See more keywords
Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates DOCA-salt-induced endothelial cell and arterial stiffening
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730293
Abstract: Introduction: Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, especially in salt-sensitive populations. To date,… read more here.
Keywords: physiology; endothelial cell; mice; doca salt ... See more keywords
Early Interleukin-6 Mediated Activation of SGK1 is Primarily via Variant 6
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731631
Abstract: Hypertension is associated with inflammation, including elevated interleukin-6 (IL-6) levels. IL-6 is an inflammatory cytokine, which we have previously shown to activate the mineralocorticoid receptor (MR) and the downstream sodium (Na) transporters- Na-chloride cotransporter (NCC)… read more here.
Keywords: early interleukin; activation; renal epithelial; physiology ... See more keywords