To die or not to die SGK1-sensitive ORAI/STIM in cell survival.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.05.001
Abstract: The pore forming Ca2+ release activated Ca2+ channel (CRAC) isoforms ORAI1-3 and their regulators STIM1,2 accomplish store operated Ca2+ entry (SOCE). Activation of SOCE may lead to cytosolic Ca2+ oscillations, which in turn support cell… read more here.
Keywords: cell survival; sgk1 dependent; orai1 stim1; orai stim ... See more keywords
Acid sphingomyelinase promotes SGK1-dependent vascular calcification.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20201122
Abstract: In chronic kidney disease (CKD), hyperphosphatemia is a key factor promoting medial vascular calcification, a common complication associated with cardiovascular events and high mortality. Vascular calcification involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs),… read more here.
Keywords: sgk1 dependent; calcification; acid sphingomyelinase; vascular calcification ... See more keywords