Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
Sign Up to like & getrecommendations! Published in 2019 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.9b00505
Abstract: SGK3 is a PX domain containing protein kinase activated at endosomes downstream of class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of… read more here.
Keywords: sgk3 protac1; sgk3; inhibitor; protac ... See more keywords
Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0087-6
Abstract: The serum and glucocorticoid-regulated kinase (SGK) family has been implicated in the regulation of many cellular processes downstream of the PI3K pathway. It plays a crucial role in PI3K-mediated tumorigenesis, making it a potential therapeutic… read more here.
Keywords: modification characterization; sgk3; identification structure; structure modification ... See more keywords
Risk of Nasopharyngeal Carcinoma Associated with Single Nucleotide Polymorphisms in the MicroRNA Binding Site of SGK3.
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DOI: 10.1089/gtmb.2019.0278
Abstract: Objective: Serum/glucocorticoid regulated kinase is a serine/threonine kinase that is involved in regulating cell proliferation, apoptosis, the cell cycle, and ion channel function. The aim of this study was to analyze the relationship between single… read more here.
Keywords: locus allele; risk; sgk3; hsa mir ... See more keywords
Serum and Glucocorticoid-Inducible Kinase 3/Nedd4-2 Signaling Pathway Participates in Podocyte Injury by Regulating the Stability of Nephrin
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DOI: 10.3389/fphys.2021.810473
Abstract: Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein. Nephrin is also one of the slit diaphragm proteins of podocytes, but whether… read more here.
Keywords: nedd4; sgk3; kinase; podocyte injury ... See more keywords