Remogliflozin: the new low cost SGLT-2 inhibitor for type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2020 at "Diabetology International"
DOI: 10.1007/s13340-020-00472-4
Abstract: SGLT-2 inhibitors have recently emerged as an important class of oral drugs for treatment of type 2 diabetes mellitus, especially in patients with cardiovascular or renal impairment, recommended in all recent treatment guidelines. They have… read more here.
Keywords: sglt inhibitor; sglt; type diabetes; diabetes mellitus ... See more keywords
Effect of SGLT-2 inhibitors on cardiovascular outcomes in heart failure patients: A meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2021.03.020
Abstract: BACKGROUND To investigate the overall effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on cardiovascular outcomes in a broad spectrum of heart failure (HF) patients, and further stratified by status of ejection fraction and diabetes mellitus. METHODS… read more here.
Keywords: failure patients; cardiovascular outcomes; sglt; heart failure ... See more keywords
Sodium influx through cerebral sodium‐glucose transporter type 1 exacerbates the development of cerebral ischemic neuronal damage
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.007
Abstract: Abstract We recently reported that cerebral sodium‐glucose transporter type 1 (SGLT‐1) plays a role in exacerbation of cerebral ischemia. However, the mechanism by which cerebral SGLT‐1 acts remains unclear. Here we demonstrated that sodium influx… read more here.
Keywords: cerebral ischemic; neuronal damage; glucose; sodium ... See more keywords
SGLT-2 Inhibitors and Cardiovascular Risk: An Analysis of CVD-REAL.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.01.085
Abstract: BACKGROUND Prior studies found patients treated with sodium-glucose co-transporter-2 inhibitors (SGLT-2i) had lower rates of death and heart failure (HF). Whether the benefits of SGLT-2i vary based upon the presence of cardiovascular disease (CVD) is… read more here.
Keywords: risk; death; sglt; cvd real ... See more keywords
Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00867
Abstract: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently approved class of oral antidiabetic drugs. SGLT-2 overexpression in diabetic patients contributes significantly to hyperglycemia and related complications. Therefore, SGLT-2 became a highly interesting therapeutic… read more here.
Keywords: antidiabetic drugs; sglt; glucose cotransporter; cotransporter inhibitors ... See more keywords
Can sodium-glucose co-transporter-2 (SGLT-2) inhibitor reduce the risk of adverse complications due to COVID-19? – Targeting hyperinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2027141
Abstract: Abstract Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are antidiabetic drugs with numerous pleiotropic and positive clinical effects, particularly regarding a reno-cardiovascular protective effect. More recent studies, including from our laboratory, have highlighted some novel anti-inflammatory activity of… read more here.
Keywords: sglt inhibitors; transporter sglt; glucose transporter; sglt ... See more keywords
Glucose transport across lagomorph jejunum epithelium is modulated by AMP-activated protein kinase under hypoxia.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00436.2017
Abstract: The gastrointestinal epithelium possesses adaptation mechanisms to cope with huge variations in blood flow and subsequently oxygenation. Since sufficient energy supply is crucial under hypoxic conditions, glucose uptake especially must be regulated by these adaptation… read more here.
Keywords: epithelium; transport; sglt; glucose transport ... See more keywords
SAT-453 Diabetic "Ketoalkalosis" Due to SGLT2 Inhibitor in the Setting of Cushing's Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-453
Abstract: Abstract Introduction - The combination of sodium glucose cotransporter-2 inhibitor (SGLT-2i) use and glucocorticoid excess can trigger ketone production by reducing insulin secretion/sensitivity and stimulating glucosuria, glucagon production, and lipolysis. In addition, metabolic alkalosis caused… read more here.
Keywords: setting cushing; dka; sglt; cushing disease ... See more keywords
SGLT-2 as a potential target in pancreatic cancer: the preliminary clue from The Cancer Genome Atlas data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-900
Abstract: Background Sodium-glucose co-transporters-2 (SGLT-2) has been reported as overexpressed in tumors including pancreatic cancer (PC). The aim of this study was to investigate the clinicopathological and prognostic significance, as well as the potential role of… read more here.
Keywords: genome atlas; pancreatic cancer; sglt; expression ... See more keywords
Mechanisms of cardiorenal protection with SGLT-2 inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Current pharmaceutical design"
DOI: 10.2174/1381612827666210119102409
Abstract: Despite optimal treatment of diabetic kidney disease (DKD) with adequate blood pressure control and agents blocking the renin-angiotensin-system (RAS), the residual cardiorenal risk of these patients remains substantially high. There is therefore an unmet need… read more here.
Keywords: cardiovascular outcomes; sglt inhibitors; sglt; cardiorenal protection ... See more keywords
Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22116044
Abstract: SGLT-2i’s exert direct anti-inflammatory and anti-oxidative effects on resting endothelial cells. However, endothelial cells are constantly exposed to mechanical forces such as cyclic stretch. Enhanced stretch increases the production of reactive oxygen species (ROS) and… read more here.
Keywords: reactive oxygen; stretch; barrier dysfunction; oxygen species ... See more keywords