Potential roles of sodium‐glucose co‐transporter 2 inhibitors in attenuating cardiac arrhythmias in diabetes and heart failure
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30727
Abstract: Sodium‐glucose co‐transporter 2 (SGLT‐2) inhibitors are antidiabetic drugs that have been shown to exert cardiovascular benefits. Their benefits including a reduction of cardiovascular events and worsening heart failure have been extended to nondiabetic patients with… read more here.
Keywords: cardiac arrhythmias; heart failure; sglt inhibitors; heart ... See more keywords
The bark giving diabetes therapy some bite: the SGLT inhibitors
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DOI: 10.1007/s00125-018-4673-4
Abstract: Following on from the success of last year’s special edition of Diabetologia, celebrating 60 years’ clinical use of metformin, for this year’s special edition we have chosen to focus on the newest class of glucose-lowering… read more here.
Keywords: sglt inhibitors; blood pressure; type diabetes; blood ... See more keywords
An Exploratory Study of Dapagliflozin for the Attenuation of Albuminuria in Patients with Heart Failure and Type 2 Diabetes Mellitus (DAPPER)
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DOI: 10.1007/s10557-018-6782-1
Abstract: Background and AimsSodium-dependent glucose transporter-2 (SGLT-2) inhibitors, which are anti-diabetic drugs, reportedly decrease the incidence of cardiovascular events in high-risk patients with cardiovascular diseases, and thus chronic heart failure (CHF). SGLT-2 inhibitors also decrease albuminuria… read more here.
Keywords: heart; sglt inhibitors; study; heart failure ... See more keywords
SGLT-2 Inhibitors in Heart Failure: Implications for the Kidneys
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DOI: 10.1007/s11897-017-0345-9
Abstract: Purpose of ReviewThis review aims to summarize the renal effects of sodium-glucose transporter-2 (SGLT-2) inhibitors and their potential implications in heart failure pathophysiology.Recent FindingsIn patients with diabetes and established atherosclerosis, the SGLT-2 inhibitor empagliflozin versus… read more here.
Keywords: inhibitors heart; heart; sglt inhibitors; heart failure ... See more keywords
Promise of SGLT2 Inhibitors in Heart Failure: Diabetes and Beyond
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DOI: 10.1007/s11936-017-0522-x
Abstract: Opinion statementThis review provides mechanistic insight in the pleiotropic effects of sodium-glucose transporter-2 (SGLT-2) inhibitors with particular interest to the pathophysiology of heart failure. The SGLT-2 inhibitor empagliflozin has recently demonstrated an unprecedented 38% reduction… read more here.
Keywords: sglt inhibitors; disease; heart failure;
SGLT-2 Inhibitors on Top of Current Pharmacological Treatments for Heart Failure: A Comparative Review on Outcomes and Cost Effectiveness
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DOI: 10.1007/s40256-021-00508-3
Abstract: Heart failure (HF) represents a major global health and economic burden with still unacceptably high morbidity and mortality rates. In recent decades, novel therapeutic opportunities with a significant impact on HF outcomes have been introduced… read more here.
Keywords: cost effectiveness; pharmacological treatments; sglt inhibitors; heart failure ... See more keywords
SGLT-2 Inhibitors and Circulating Progenitor Cells in Diabetes.
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DOI: 10.1016/j.cmet.2020.04.002
Abstract: Hess et al. recently hypothesized that shifts in circulating progenitor cell populations may drive cardiovascular protection by SGLT-2 inhibitors in patients with type 2 diabetes. In this Letter, Fadini challenges that interpretation and discusses previous findings… read more here.
Keywords: progenitor cells; circulating progenitor; inhibitors circulating; sglt inhibitors ... See more keywords
Role of Sodium-Glucose Cotransporter-2 Inhibition in the Treatment of Adults With Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2019.08.012
Abstract: Diabetes and heart failure (HF) independently contribute to significant cardiovascular (CV) morbidity and mortality. Both are tremendous burdens to health-care systems. Among patients with established HF, diabetes mellitus is one of the most common comorbidities,… read more here.
Keywords: among patients; sglt inhibitors; sodium glucose; glucose cotransporter ... See more keywords
SGLT-2 inhibitors for COVID-19 — A miracle waiting to happen or just another beat around the bush?
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DOI: 10.1016/j.pcd.2020.05.013
Abstract: Inhibitors of Sodium-Glucose transporter (SGLT-2) are among the newest pharmacotherapeutics to be evaluated for the management of 2019-Coronavirus disease (COVID-19). Few hypotheses like reduced lactatemia, inhibition of Na-H exchanger, reduction of proinflammatory cytokines, augmentation of… read more here.
Keywords: sglt inhibitors; waiting happen; happen another; covid miracle ... See more keywords
CONTEMPORARY NATIONAL PATTERNS OF ELIGIBILITY AND UTILIZATION OF NOVEL CARDIOPROTECTIVE ANTI-HYPERGLYCEMIC AGENTS IN TYPE 2 DIABETES
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DOI: 10.1016/s0735-1097(21)02893-x
Abstract: Background Sodium glucose transporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) effectively lowered cardiovascular risk in large clinical trials for patients with type 2 diabetes at high risk for these complications, and have recommended… read more here.
Keywords: inhibitors glp; contemporary national; sglt inhibitors; type diabetes ... See more keywords
Can sodium-glucose co-transporter-2 (SGLT-2) inhibitor reduce the risk of adverse complications due to COVID-19? – Targeting hyperinflammation
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DOI: 10.1080/03007995.2022.2027141
Abstract: Abstract Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are antidiabetic drugs with numerous pleiotropic and positive clinical effects, particularly regarding a reno-cardiovascular protective effect. More recent studies, including from our laboratory, have highlighted some novel anti-inflammatory activity of… read more here.
Keywords: sglt inhibitors; transporter sglt; glucose transporter; sglt ... See more keywords