Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4656-5
Abstract: The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is… read more here.
Keywords: glucose handling; sglt2; physiology; renal glucose ... See more keywords
Optimizing SGLT inhibitor treatment for diabetes with chronic kidney diseases
Sign Up to like & getrecommendations! Published in 2018 at "Biological Cybernetics"
DOI: 10.1007/s00422-018-0765-y
Abstract: Diabetes induces glomerular hyperfiltration, affects kidney function, and may lead to chronic kidney diseases. A novel therapeutic treatment for diabetic patients targets the sodium–glucose cotransporter isoform 2 (SGLT2) in the kidney. SGLT2 inhibitors enhance urinary… read more here.
Keywords: chronic kidney; kidney diseases; treatment; inhibition ... See more keywords
A case of anti-HMGCR myopathy triggered by sodium/glucose co-transporter 2 (SGLT2) inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Sciences"
DOI: 10.1007/s10072-022-06046-3
Abstract: Inflammatory myopathies, including immune-mediated necrotizing myopathy (IMNM), are a rare and heterogeneous group of autoimmune diseases which can even involve extramuscular districts and seriously impact patients’ quality of life. We report the case of a… read more here.
Keywords: sglt2; case; glucose transporter; transporter sglt2 ... See more keywords
Effect of SGLT2 inhibitor on renal function in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "International Urology and Nephrology"
DOI: 10.1007/s11255-019-02112-6
Abstract: ObjectiveThis study summarizes the evidence from randomized controlled trials (RCTs) to assess the effects of SGLT2 inhibitors on renal function and albuminuria in patients with type 2 diabetes.Materials/methodsWe searched PubMed, Web of Science, Cochrane Library… read more here.
Keywords: patients type; randomized controlled; sglt2; effect ... See more keywords
Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease
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DOI: 10.1007/s11892-021-01442-z
Abstract: Purpose of Review This review offers a critical narrative evaluation of emerging evidence that sodium-glucose co-transporter-2 (SGLT2) inhibitors exert nephroprotective effects in people with type 2 diabetes. Recent Findings The SGLT2 inhibitor class of glucose-lowering… read more here.
Keywords: protection sglt2; sglt2 inhibitors; sglt2; renal protection ... See more keywords
Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors: Are They All the Same? A Narrative Review of Cardiovascular Outcome Trials
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00951-6
Abstract: Clinically important improvements in cardiovascular risk factors and adverse cardiovascular, heart failure and renal outcomes have been observed in numerous cardiovascular outcome trials (CVOTs) investigating the use of sodium-glucose co-transporter 2 (SGLT2) inhibitors over the last… read more here.
Keywords: sglt2 inhibitors; sodium glucose; glucose transporter; cardiovascular outcome ... See more keywords
Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108995
Abstract: Failing pancreas and subsequent loss of pancreatic β cells worsen diabetic conditions which are further alleviated by the mounting up of glucose levels. Inhibition of sodium glucose cotransporter 2 (SGLT2) in the kidney responsible for… read more here.
Keywords: swertisin; glucose homeostasis; diabetes therapy; sglt2 ... See more keywords
Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells
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DOI: 10.1038/s41598-019-41253-7
Abstract: Several clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on diabetic nephropathy. The underlying mechanisms are not fully understood. We found that administration of canagliflozin at a low dose (0.01 mg/kg/day)… read more here.
Keywords: sglt2 inhibitors; sglt2 mesangial; role sglt2; sglt2 ... See more keywords
Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans
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DOI: 10.1080/00498254.2019.1654634
Abstract: Abstract Bexagliflozin is a C-aryl glucoside inhibitor of human sodium-glucose linked transporter 2 (SGLT2) that undergoes oxidation and glucuronidation to form six principal metabolites in humans. In vitro metabolism by human liver microsomes and recombinant… read more here.
Keywords: monkeys humans; inhibitor; metabolism; bexagliflozin ... See more keywords
Retrospective review of SGLT2 inhibitor exposures reported to 13 poison centers
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Toxicology"
DOI: 10.1080/15563650.2017.1357824
Abstract: Abstract Background: SGLT2 inhibitors are a new class of oral antidiabetics prescribed in the United States since 2013. They act by inhibiting reabsorption of glucose in the proximal convoluted tubule of the kidney, allowing excess… read more here.
Keywords: sglt2 inhibitors; review sglt2; poison centers; sglt2 ... See more keywords
SGLT2 inhibitors: practical considerations and recommendations for cardiologists.
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DOI: 10.1097/hco.0000000000000561
Abstract: PURPOSE OF REVIEW To address common concerns regarding sodium-glucose cotransporter 2 (SGLT2) inhibitor use for patients with type 2 diabetes mellitus (T2DM) in cardiovascular practice. RECENT FINDINGS SGLT2 inhibitors provide glycemic control and improve cardiovascular… read more here.
Keywords: sglt2 inhibitors; sglt2; practical considerations; glycemic control ... See more keywords