SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.08.015
Abstract: Hess et al. quantified circulating aldehyde dehydrogenase-expressing (ALDHhi) cell subsets in people with T2DM given either empagliflozin (EMPA) or placebo. EMPA treatment increased circulating pro-angiogenic CD133+ progenitor cells, decreased pro-inflammatory ALDHhi granulocyte precursors, and increased ALDHhi… read more here.
Keywords: progenitor cells; empagliflozin increases; inhibition empagliflozin; increases circulating ... See more keywords
Adaptive Response as a Potential Key Link Between SGLT2 Inhibition and Renoprotection
Sign Up to like & getrecommendations! Published in 2021 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2021.05.035
Abstract: G rowing attention has been focused on the benefits of sodium glucose cotransporter-2 (SGLT2) inhibitors, a novel class of oral hypoglycemic agents, in nephrology and diabetology. In Kidney International Reports, Liu et al. reported an… read more here.
Keywords: key link; adaptive response; potential key; link sglt2 ... See more keywords
Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.04.025
Abstract: It is unclear whether long-term sodium-glucose cotransporter 2 (SGLT2) inhibition such as that during the treatment of diabetes has deleterious effects on the kidney. Therefore, we first sought to determine whether abnormal glucose metabolism occurs… read more here.
Keywords: calorie restriction; inhibition; glucose metabolism; diabetic mice ... See more keywords
SGLT2 inhibition and kidney protection.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20171298
Abstract: Type 2 diabetes mellitus (T2DM) is a growing public health concern worldwide. Numerous drug classes are available for treatment, however, their efficacy with regard to diabetes-induced renal and cardiovascular (CV) complications remains limited. Inhibitors of… read more here.
Keywords: sglt2 inhibitors; inhibition kidney; inhibition; sglt2 inhibition ... See more keywords
An evaluation of empagliflozin and it’s applicability to hypertension as a therapeutic option
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1751815
Abstract: ABSTRACT Introduction Sodium-glucose cotransporter 2 (SGLT2) inhibitors such as Empagliflozin are novel antihyperglycemic drugs approved for the treatment of type 2 diabetes (T2D). In addition to its glucose-lowering effects, Empagliflozin promotes weight loss, blood pressure… read more here.
Keywords: type diabetes; blood pressure; sglt2 inhibition;
SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
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DOI: 10.2337/dc22-0323
Abstract: OBJECTIVE To investigate the causal role of choline metabolites mediating sodium–glucose cotransporter 2 (SGLT2) inhibition in coronary artery disease (CAD) and type 2 diabetes (T2D) using Mendelian randomization (MR). RESEARCH DESIGN AND METHODS A two-sample… read more here.
Keywords: inhibition; cad; sglt2 inhibition; choline metabolites ... See more keywords
Effects of the SGLT2 Inhibition on Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats, a Model of Type 1 Diabetes Mellitus
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DOI: 10.3390/antiox11050982
Abstract: Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. As most studies were performed in Type 2 DM, the cardiovascular effects of SGLT2 inhibition still… read more here.
Keywords: effects sglt2; dapa; sglt2 inhibition; model type ... See more keywords