Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues.
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DOI: 10.1016/j.xphs.2019.03.030
Abstract: The glycopyrrolate soft analog, SGM, designed to be easily hydrolyzed into the significantly less active zwitterionic metabolite, SGa, typifies soft drug that reduces systemic side effects (a problem often seen with traditional anticholinergics) following local… read more here.
Keywords: sgm; 2r3 sgm; hydrolysis; human rat ... See more keywords