A Self-assembled Platform Based on Branched DNA for sgRNA/Cas9/Antisense Delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b09043
Abstract: Precisely assembled DNA nanostructures are promising candidates for the delivery of biomolecule-based therapeutics. Herein, we introduce a facile strategy for the construction of a branched DNA-based nanoplatform for co-delivery of gene editing (sgRNA/Cas9, targeting DNA… read more here.
Keywords: dna; delivery; sgrna cas9; branched dna ... See more keywords
An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm00427h
Abstract: CRISPR-Cas9 is a versatile genome-editing technology that is a promising gene therapy tactic. However, the delivery of CRISPR-Cas9 is still a major obstacle to its broader clinical application. Here, we confirm that the components of… read more here.
Keywords: crispr cas9; cas9; recipient cells; sgrna cas9 ... See more keywords