Introduction: History of SH2 Domains and Their Applications.
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DOI: 10.1007/978-1-4939-6762-9_1
Abstract: The Src Homology 2 (SH2) domain is the prototypical protein interaction module that lies at the heart of phosphotyrosine signaling. Since its serendipitous discovery, there has been a tremendous advancement in technologies and an array… read more here.
Keywords: sh2 domains; history sh2; sh2; biology ... See more keywords
Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain.
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DOI: 10.1007/978-1-4939-6762-9_13
Abstract: Commercial antibodies raised against phosphotyrosine have been widely used as reagents to detect or isolate tyrosine-phosphorylated proteins from cellular samples. However, these antibodies are costly and are not amenable to in-house production in an academic… read more here.
Keywords: creation phosphotyrosine; sh2; phosphotyrosine superbinders; sh2 domain ... See more keywords
Structural Characterization of Monomeric/Dimeric State of p59fyn SH2 Domain.
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DOI: 10.1007/978-1-4939-6762-9_14
Abstract: Src homology 2 (SH2) domains are key modulators in various signaling pathways allowing the recognition of phosphotyrosine sites of different proteins. Despite the fact that SH2 domains acquire their biological functions in a monomeric state,… read more here.
Keywords: state; p59fyn sh2; sh2; state p59fyn ... See more keywords
Classification and Lineage Tracing of SH2 Domains Throughout Eukaryotes.
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DOI: 10.1007/978-1-4939-6762-9_4
Abstract: Today there exists a rapidly expanding number of sequenced genomes. Cataloging protein interaction domains such as the Src Homology 2 (SH2) domain across these various genomes can be accomplished with ease due to existing algorithms… read more here.
Keywords: tracing sh2; sh2 domains; sh2; domains throughout ... See more keywords
Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET.
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DOI: 10.1016/j.abb.2018.08.012
Abstract: SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) binds with the Y1356-phosphorylated hepatocyte growth factor (HGF) receptor, c-MET, through its SH2 domain, which is essential for the role of SHIP2 in HGF-induced cell scattering and cell spreading.… read more here.
Keywords: sh2; ship2 sh2; structure; sh2 domain ... See more keywords
Identification and characterization of a large family of superbinding bacterial SH2 domains
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DOI: 10.1038/s41467-018-06943-2
Abstract: Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). Apart from a few isolated cases in viruses, no functional SH2 domain has been… read more here.
Keywords: sh2 domains; bacterial sh2; sh2; large family ... See more keywords
Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening
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DOI: 10.1039/c7ra07445j
Abstract: The Src SH2 domain was synthesized via native chemical ligation of two fragment peptides. The facile protocol was used to prepare the mirror-image SH2 domain (D-Src SH2 domain) and tetramethylrhodamine-labeled SH2 domains. The synthesized SH2… read more here.
Keywords: sh2 domain; mirror image; sh2; src sh2 ... See more keywords
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116815119
Abstract: Significance Src homology 2 (SH2) domains are phosphotyrosine binding motifs that play key roles in cellular signaling. There are 110 proteins in the human genome containing SH2 binding domains, of which 10 contain tandem SH2… read more here.
Keywords: cell receptor; zap70; sh2 domains; sh2 ... See more keywords
SH2db, an information system for the SH2 domain.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad420
Abstract: SH2 domains are key mediators of phosphotyrosine-based signalling, and therapeutic targets for diverse, mostly oncological, disease indications. They have a highly conserved structure with a central beta sheet that divides the binding surface of the… read more here.
Keywords: sh2 domain; sh2db information; information system; sh2 ... See more keywords
The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
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DOI: 10.1371/journal.pone.0261098
Abstract: JAK2 is cytokine-activated non-receptor tyrosine kinase. Although JAK2 is mainly localized at the plasma membrane, it is also present on the centrosome. In this study, we demonstrated that JAK2 localization to the centrosome depends on… read more here.
Keywords: sh2 domain; kinase activity; jak2; sh2 ... See more keywords
Allelic variation in shrunken2 gene affecting kernel sweetness in exotic-and indigenous-maize inbreds
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DOI: 10.1371/journal.pone.0274732
Abstract: Sweet corn has become a popular food worldwide. It possesses six-times more sugar than field corn due to the presence of recessive shrunken2 (sh2) gene. Despite availability of diverse sweet corn germplasm, comprehensive characterization of… read more here.
Keywords: sweet corn; sh2; maize inbreds; gene ... See more keywords