MIR22HG Aggravates Oxygen-Glucose Deprivation and Reoxygenation-Induced Cardiomyocyte Injury through the miR-9-3p/SH2B3 Axis
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DOI: 10.1155/2022/7332298
Abstract: Reperfusion therapy, the standard treatment for acute myocardial infarction (MI), can trigger necrotic death of cardiomyocytes and provoke ischemia/reperfusion (I/R) injury. However, molecular mechanisms that regulate cardiomyocyte death remain largely unknown. The abnormal expression of… read more here.
Keywords: sh2b3; glucose deprivation; mir22hg; oxygen glucose ... See more keywords
SH2B3 (lnk) Regulates Type 1 Diabetes Immune Phenotypes
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DOI: 10.2337/db18-224-lb
Abstract: Background: The type 1 diabetes (T1D)-associated risk gene SH2B Adaptor Protein 3 (SH2B3) encodes a phosphatase with specificity for Janus Kinase 2 (JAK2). We hypothesized that variations in SH2B3 would affect immune signaling pathways relevant… read more here.
Keywords: risk variant; t1d; risk; variant ... See more keywords