ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03610-y
Abstract: SAM68 is an mRNA-binding protein involved in mRNA processing in the nucleus that forms membraneless compartments called SAM68 Nuclear Bodies (SNBs). We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3… read more here.
Keywords: sam68 proline; proline rich; sh3; sh3 domain ... See more keywords
Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00717
Abstract: An increase in phosphorylation of the Tau protein is associated with Alzheimer's disease (AD) progression through unclear molecular mechanisms. In general, phosphorylation modifies the interaction of intrinsically disordered proteins, such as Tau, with other proteins;… read more here.
Keywords: sh3; affinity; bin1 sh3; tau protein ... See more keywords
Aminoquinoline-Rhodium(II) Conjugates as Src-Family SH3 Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00309
Abstract: High-affinity, selective ligands are sought for a variety of biomolecules but are particularly difficult to generate in the protein-protein interaction space. Rhodium(II) conjugates provide a structure-based approach to improved affinity and specificity for targeting protein-protein… read more here.
Keywords: protein; rhodium conjugates; rhodium; sh3 ... See more keywords
A novel flow cytometry assay based on bacteriophage-derived proteins for Staphylococcus detection in blood
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62533-7
Abstract: Bloodstream infections (BSIs) are considered a major cause of death worldwide. Staphylococcus spp. are one of the most BSIs prevalent bacteria, classified as high priority due to the increasing multidrug resistant strains. Thus, a fast,… read more here.
Keywords: detection; sh3; cytometry assay; blood ... See more keywords
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1101/2022.08.11.503583
Abstract: Clathrin-mediated endocytosis is a conserved eukaryotic membrane trafficking pathway that is driven by a sequentially assembled molecular machinery that contains over 60 different proteins. SH3 domains are the most abundant protein-protein interaction domain in this… read more here.
Keywords: sh3; domain; sh3 domains; regulation endocytic ... See more keywords
The Ca2+ channel subunit CaVβ2a‐subunit down‐regulates voltage‐activated ion current densities by disrupting actin‐dependent traffic in chromaffin cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14851
Abstract: β‐Subunits of the Ca2+ channel have been conventionally regarded as auxiliary subunits that regulate the expression and activity of the pore‐forming α1 subunit. However, they comprise protein–protein interaction domains, such as a SRC homology 3… read more here.
Keywords: chromaffin cells; sh3; ca2 channel; subunit ... See more keywords
Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158103
Abstract: The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation of podosomes and invadopodia. In addition, Tks4 is involved… read more here.
Keywords: sh3 domain; sh3; scaffold protein; protein tks4 ... See more keywords