ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03610-y
Abstract: SAM68 is an mRNA-binding protein involved in mRNA processing in the nucleus that forms membraneless compartments called SAM68 Nuclear Bodies (SNBs). We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3… read more here.
Keywords: sam68 proline; proline rich; sh3; sh3 domain ... See more keywords
SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.10.107
Abstract: Lung cancer is one of the most common and aggressive cancer and a leading cause of cancer related deaths worldwide. Few studies have prospectively examined the functions of SH3GL3 in cancer progression, however, the biological… read more here.
Keywords: sh3 domain; tumor suppressor; lung cancer; potent tumor ... See more keywords
The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.01.019
Abstract: Src homology 3 or SH3 domains constitute one of the most common protein domains in signal transduction, generally characterized by their binding to proline-rich sequences on interacting signaling proteins. Caskin1, a scaffold protein regulating cortical… read more here.
Keywords: caskin1; sh3 domain; lysophosphatidic acid; proline rich ... See more keywords
Stepwise Assembly of β-Sheet Structure during the Folding of an SH3 Domain Revealed by a Pulsed Hydrogen Exchange Mass Spectrometry Study.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00374
Abstract: Dissecting temporally the sequence of secondary structural changes, and determining how these specific changes modulate conformational heterogeneity, remain major goals of protein folding studies. In this study, the folding of the SH3 domain of PI3… read more here.
Keywords: sh3 domain; exchange mass; folding sh3; hydrogen exchange ... See more keywords
Down‐regulation and clinical significance of Sorbin and SH3 domain‐containing protein 1 in bladder cancer tissues
Sign Up to like & getrecommendations! Published in 2023 at "IET Systems Biology"
DOI: 10.1049/syb2.12060
Abstract: Abstract Bladder cancer (BC) is a common cancer worldwide with a high prevalence. This study was conducted to elucidate the expression and clinical significance of Sorbin and SH3 domain‐containing protein 1 (SORBS1) in BC as… read more here.
Keywords: clinical significance; sorbin sh3; sh3 domain; bladder cancer ... See more keywords
Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158103
Abstract: The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation of podosomes and invadopodia. In addition, Tks4 is involved… read more here.
Keywords: sh3 domain; sh3; scaffold protein; protein tks4 ... See more keywords