Shank3‐deficient rats exhibit degraded cortical responses to sound
Sign Up to like & getrecommendations! Published in 2018 at "Autism Research"
DOI: 10.1002/aur.1883
Abstract: Individuals with SHANK3 mutations have severely impaired receptive and expressive language abilities. While brain responses are known to be abnormal in these individuals, the auditory cortex response to sound has remained largely understudied. In this… read more here.
Keywords: deficient rats; shank3 deficient; auditory cortex; cortex response ... See more keywords
Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0351-2
Abstract: Many of the genes disrupted in autism are identified as histone-modifying enzymes and chromatin remodelers, most prominently those that mediate histone methylation/demethylation. However, the role of histone methylation enzymes in the pathophysiology and treatment of… read more here.
Keywords: shank3 deficient; autism like; autism; deficient mice ... See more keywords