Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.05.015
Abstract: Recent studies have determined that the microbiome has direct effects on behavior, and may be dysregulated in neurodevelopmental conditions. Considering that neurodevelopmental conditions, such as autism, have a strong genetic etiology, it is necessary to… read more here.
Keywords: shank3 mice; autism; treatment; probiotic treatment ... See more keywords
Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Brain"
DOI: 10.1186/s13041-018-0403-6
Abstract: The SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene encodes core scaffolds in neuronal excitatory postsynapses. SHANK3 duplications have been identified in patients with hyperkinetic disorders and early-onset generalized tonic-clonic seizures. Consistently, Shank3 transgenic… read more here.
Keywords: seizure partial; spontaneous seizure; shank3 mice; shank3 ... See more keywords