Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Autistic-Like Behaviors of SHANK3 Mutant Beagle Dogs
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szac028
Abstract: Abstract Mesenchymal stem cell-based therapy has emerged as a great potential approach to treat individuals with autism spectrum disorders (ASD), a group of developmental disabilities characterized by impairments in social interaction and communication. Stem cells… read more here.
Keywords: mutant beagle; beagle dogs; cells human; shank3 mutant ... See more keywords
Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1017512
Abstract: Shank3 is an abundant excitatory postsynaptic scaffolding protein implicated in various neurodevelopmental disorders, including autism spectrum disorder (ASD), Phelan-McDermid syndrome, intellectual disability, and schizophrenia. Shank3-mutant mice show various molecular, synaptic, and behavioral deficits, but little… read more here.
Keywords: shank3 mutant; transcriptomic changes; mutant mice; gene ... See more keywords