Age-dependent decrease of GAD65/67 mRNAs but normal densities of GABAergic interneurons in the brain regions of Shank3-overexpressing manic mouse model
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DOI: 10.1016/j.neulet.2017.04.016
Abstract: Dysfunction of inhibitory GABAergic interneurons is considered a major pathophysiological feature of various neurodevelopmental and neuropsychiatric disorders. The variants of SHANK3 gene, encoding a core scaffold protein of the excitatory postsynapse, have been associated with… read more here.
Keywords: gad65; shank3 transgenic; transgenic mice; mice ... See more keywords