Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.064469.117
Abstract: The impact of inherited and somatic mutations on messenger RNA (mRNA) structure remains poorly understood. Recent technological advances that leverage next-generation sequencing to obtain experimental structure data, such as SHAPE-MaP, can reveal structural effects of… read more here.
Keywords: mrna structure; tpt1 lcp1; structure; shape map ... See more keywords
The Evaluation of SHAPE-MaP RNA Structure Probing Protocols Reveals a Novel Role of Mn2+ in the Detection of 2′-OH Adducts
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097890
Abstract: Chemical probing, for decades, has been one of the most popular tools for studying the secondary structure of RNA molecules. Recently, protocols for simultaneous analysis of multiple RNAs have been developed, enabling in vivo transcriptome-wide… read more here.
Keywords: rna structure; shape map; structure; rna ... See more keywords