Is the bell-shaped dose-response curve of the selective serotonin reuptake inhibitor due to 5-HT1A auto-receptors?
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109681
Abstract: A dose-response curve is a plot of drug efficacy versus dose. Interestingly, some antidepressants show a bell-shaped dose-response curve where increasing dose leads to increasing efficacy only up to a point, whereupon further increases lead… read more here.
Keywords: dose response; shaped dose; response; bell shaped ... See more keywords
Discovery of a bell-shaped dose response curve to melanin-concentrating hormone in the 3T3-L1 adipocyte model: low-dose MCH facilitates adipogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Adipocyte"
DOI: 10.1080/21623945.2025.2594882
Abstract: ABSTRACT Melanin-concentrating hormone signalling pathways in the central nervous system are of significant clinical interest in treating appetite, sleep, and mood disorders. However, with the additional discovery of active MCH signalling pathways in peripheral tissues,… read more here.
Keywords: melanin concentrating; shaped dose; concentrating hormone; mch ... See more keywords
Evidence for Bell-Shaped Dose-Response Emetic Effects of Temsirolimus and Analogs: The Broad-Spectrum Antiemetic Efficacy of a Large Dose of Temsirolimus Against Diverse Emetogens in the Least Shrew (Cryptotis parva)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.848673
Abstract: Temsirolimus is a prodrug form of sirolimus (rapamycin). With its analogs (everolimus, ridaforolimus, and rapamycin), it forms a group of anticancer agents that block the activity of one of the two mammalian targets of rapamycin… read more here.
Keywords: shaped dose; least shrew; dose temsirolimus; bell shaped ... See more keywords