Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils.
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DOI: 10.1021/acschemneuro.2c00416
Abstract: The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is implicated in amyotrophic lateral sclerosis (ALS), and some hereditary mutations localized in the low complexity domain (LCD) facilitate the formation of… read more here.
Keywords: shaped protofilaments; atomistic insights; a315e mutation; tdp ... See more keywords