Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants
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DOI: 10.7554/elife.61487
Abstract: Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. We… read more here.
Keywords: shapes folding; cancer; zinc shapes; zinc ... See more keywords