Mutational Processes Shaping the Genome in Early Human Embryos
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.008
Abstract: In-vitro-fertilized human embryos often acquire large structural and numerical chromosomal abnormalities. Liu et al. now show that multiple smaller copy number variations may also arise in in-vivo-conceived embryos. Analysis of these variations provides insight into the… read more here.
Keywords: human embryos; early human; shaping genome; genome early ... See more keywords
Shaping the genome via lengthwise compaction, phase separation, and lamina adhesion
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.02.28.482402
Abstract: The link between genomic structure and biological function is yet to be consolidated, it is, however, clear that physical manipulation of the genome, driven by the activity of a variety of proteins, is a crucial… read more here.
Keywords: adhesion; compaction; shaping genome; lengthwise compaction ... See more keywords