Integrative Biological Network Analysis to Identify Shared Genes in Metabolic Disorders
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2020.2993301
Abstract: Identification of common molecular mechanisms in interrelated diseases is essential for better prognoses and targeted therapies. However, complexity of metabolic pathways makes it difficult to discover common disease genes underlying metabolic disorders; and it requires… read more here.
Keywords: network analysis; identify shared; shared genes; metabolic disorders ... See more keywords
Migraine and thyroid dysfunction: Co‐occurrence, shared genes and biological mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neurology"
DOI: 10.1111/ene.15753
Abstract: Migraine and thyroid dysfunction, particularly hypothyroidism, are common medical conditions and are known to have high heritability. Thyroid function measures, thyroid stimulating hormone (TSH) and free thyroxine (fT4), are also known to be genetically influenced.… read more here.
Keywords: shared genes; dysfunction occurrence; migraine thyroid; occurrence shared ... See more keywords
Identification of the shared genes in type 2 diabetes mellitus and osteoarthritis and the role of quercetin
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18127
Abstract: This study investigated the underlying comorbidity mechanism between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA), while also assessing the therapeutic potential of quercetin for early intervention and treatment of these two diseases. The shared… read more here.
Keywords: diabetes mellitus; quercetin; type diabetes; shared genes ... See more keywords
Exploration of the molecular mechanisms, shared gene signatures, and MicroRNAs between systemic lupus erythematosus and diffuse large B cell lymphoma by bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2022 at "Lupus"
DOI: 10.1177/09612033221114578
Abstract: Background Systemic lupus erythematosus (SLE) is a complex heterogeneous systemic autoimmune disease. Previous studies have shown that SLE may be related to diffuse large B cell lymphoma (DLBCL), but the mechanism of their relationship is… read more here.
Keywords: core; shared genes; systemic lupus; analysis ... See more keywords
Transcriptomic insights into the genetic basis of mammalian limb diversity
Sign Up to like & getrecommendations! Published in 2017 at "BMC Evolutionary Biology"
DOI: 10.1186/s12862-017-0902-6
Abstract: BackgroundFrom bat wings to whale flippers, limb diversification has been crucial to the evolutionary success of mammals. We performed the first transcriptome-wide study of limb development in multiple species to explore the hypothesis that mammalian… read more here.
Keywords: fore hind; limb; shared genes; mammalian limb ... See more keywords
A disease similarity matrix based on the uniqueness of shared genes
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Genomics"
DOI: 10.1186/s12920-017-0265-2
Abstract: BackgroundComplex diseases involve many genes, and these genes are often associated with several different illnesses. Disease similarity measurement can be based on shared genotype or phenotype. Quantifying relationships between genes can reveal previously unknown connections… read more here.
Keywords: ontology; disease similarity; similarity; disease ... See more keywords
Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s497201
Abstract: Background Associations between ulcerative colitis (UC) and ankylosing spondylitis (AS) have been reported in multiple studies, but the common etiologies of UC and AS remain unknown. Thus, in the current study, we aimed to investigate… read more here.
Keywords: colitis ankylosing; shared genes; ulcerative colitis; key genes ... See more keywords
Exploration of shared gene signature with development of pre-eclampsia and cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.972346
Abstract: Background: The relationship between pre-eclampsia (PE) and cervical cancer (CC) has drawn more attention recently, while little is known about the shared pathogenesis of CC and PE. In the present research, we aimed to generate… read more here.
Keywords: shared genes; signature; development; pre eclampsia ... See more keywords
Shared genetic architecture between the two neurodegenerative diseases: Alzheimer’s disease and glaucoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.880576
Abstract: Background Considered as the representatives of neurodegenerative diseases, Alzheimer’s disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic and environmental risk factors and cause irreversible damages. Current research indicates that there are… read more here.
Keywords: diseases alzheimer; glaucoma; disease glaucoma; shared genes ... See more keywords