Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4974
Abstract: Key Points Question To what extent are shared genetic determinants in the comorbidities and associations between gastrointestinal tract diseases and psychiatry disorders involved in the gut-brain axis? Findings In this genome-wide pleiotropic association study using… read more here.
Keywords: brain axis; shared genetic; etiology; gut brain ... See more keywords
Shared genetic risk between anorexia nervosa and cardiovascular disease events: Evidence from genome‐wide association studies
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3294
Abstract: Cardiovascular complications occur in up to 80% of patients with anorexia nervosa (AN), yet the underlying mechanisms warrant further investigation. We assessed the genetic correlation (rg) between AN and cardiovascular disease (CVD) events to inform… read more here.
Keywords: cardiovascular disease; anorexia nervosa; shared genetic; genetic risk ... See more keywords
Analysis of family histories suggests shared genetic risk for chronic thromboembolic pulmonary hypertension and venous thromboembolism
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12170
Abstract: Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) and acute pulmonary embolism (PE) are related phenotypes, however, previous reports have suggested that genetic risk factors for CTEPH and PE differ. Here we report that a family history… read more here.
Keywords: pulmonary hypertension; shared genetic; thromboembolic pulmonary; risk ... See more keywords
Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications
Sign Up to like & getrecommendations! Published in 2025 at "Diabetologia"
DOI: 10.1007/s00125-025-06403-9
Abstract: Diabetes is a rapidly growing global health concern projected to affect one in eight adults by 2045, which translates to roughly 783 million people. The profound metabolic alterations often present in dysglycaemia significantly increase the… read more here.
Keywords: disease; diabetes cardiovascular; shared genetic; cardiovascular complications ... See more keywords
M61 Shared Genetic Variants Between Schizophrenia And General Cognitive Function Indicate Common Molecular Genetic Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.452
Abstract: Background: Schizophrenia (SCZ) is a severe mental disorder characterized by widespread cognitive impairments including deficits in learning, memory, processing speed, attention and executive funct ... read more here.
Keywords: variants schizophrenia; m61 shared; schizophrenia general; genetic variants ... See more keywords
Shared genetic influences among childhood shyness, social competences, and cortical responses to emotions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of experimental child psychology"
DOI: 10.1016/j.jecp.2017.03.012
Abstract: Visual event-related potentials (ERPs) evoked by facial expressions are useful to map socioemotional responses among shy children and to predict transition into social phobia. We investigated the sources of covariation among childhood shyness, social competences,… read more here.
Keywords: shared genetic; social competences; shyness social; among childhood ... See more keywords
Shared genetic effects of emotion and subcortical volumes in healthy adults
Sign Up to like & getrecommendations! Published in 2022 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2022.118894
Abstract: Ample studies have reported a strong association between emotion and subcortical volumes; still, the underlying mechanism regarding this relation remains unclear. Using a twin design, the current study aimed to explore the intrinsic association between… read more here.
Keywords: genetic effects; subcortical volumes; shared genetic; caudate volume ... See more keywords
Shared genetic risk factors for depression and stroke
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.03.003
Abstract: BACKGROUND The comorbidity of major depressive disorder (MDD) and stroke are common in clinic. There is a growing body of evidence suggesting a bi-directional relationship between stroke and depression. However, the mechanisms underlying the relationship… read more here.
Keywords: risk; risk factors; mdd stroke; shared genetic ... See more keywords
Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits
Sign Up to like & getrecommendations! Published in 2018 at "Psychological Medicine"
DOI: 10.1017/s0033291718001812
Abstract: Abstract Background Cardiovascular diseases represent a major health issue in patients with schizophrenia (SCZ) and bipolar disorder (BD), but the exact nature of cardiometabolic (CM) abnormalities involved and the underlying mechanisms remain unclear. Psychiatric medications… read more here.
Keywords: exploring shared; genetic bases; bipolar disorder; shared genetic ... See more keywords
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis.
Sign Up to like & getrecommendations! Published in 2024 at "Psychological medicine"
DOI: 10.1017/s0033291724000771
Abstract: BACKGROUND The comorbidity between schizophrenia (SCZ) and inflammatory bowel disease (IBD) observed in epidemiological studies is partially attributed to genetic overlap, but the magnitude of shared genetic components and the causality relationship between them remains… read more here.
Keywords: disease; scz ibd; ibd; analysis ... See more keywords
Shared genetic aetiology between cognitive performance and brain activations in language and math tasks
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35665-0
Abstract: Cognitive performance is highly heritable. However, little is known about common genetic influences on cognitive ability and brain activation when engaged in a cognitive task. The Human Connectome Project (HCP) offers a unique opportunity to… read more here.
Keywords: etiology; cognitive performance; language; performance ... See more keywords