An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
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DOI: 10.1016/j.str.2018.02.017
Abstract: Small conductance potassium (SK) ion channels define neuronal firing rates by conducting the after-hyperpolarization current. They are key targets in developing therapies where neuronal firing rates are dysfunctional, such as in epilepsy, Parkinson's, and amyotrophic… read more here.
Keywords: intracellular allosteric; binding pocket; ion channels; shared multiple ... See more keywords