Effect of Synthetic High Density Lipoproteins Modification with Polyethylene Glycol on Pharmacokinetics and Pharmacodynamics.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00734
Abstract: Synthetic high density lipoprotein nanoparticles (sHDLs) capable of mobilizing excess cholesterol from atherosclerotic arteries and delivering it to the liver for elimination have been shown to reduce plaque burden in patients. Unfortunately, sHDLs have a… read more here.
Keywords: high density; modification polyethylene; synthetic high; cholesterol ... See more keywords
Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abd0130
Abstract: sHDL is a promising antithrombotic agent delivery system due to its antithrombotic effect itself and improved drug delivery. Antiplatelet agents offer a desirable approach to thrombosis prevention through the reduction of platelet reactivity. However, major… read more here.
Keywords: high density; antiplatelet drug; synthetic high; drug ... See more keywords
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abl9322
Abstract: Sepsis is a major health issue with mortality exceeding 30% and few treatment options. We found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in septic patients compared to that in nonseptic patients.… read more here.
Keywords: sepsis; replenishing hdl; synthetic hdl; shdl ... See more keywords