In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.
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DOI: 10.1007/s10439-021-02790-3
Abstract: Platelet adhesion to blood vessel walls in shear flow is essential to initiating the blood coagulation cascade and prompting clot formation in vascular disease processes and prosthetic cardiovascular devices. Validation of predictive adhesion kinematics models… read more here.
Keywords: platelet adhesion; shear mediated; kinematics; adhesion kinematics ... See more keywords
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
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DOI: 10.1038/s41598-021-85199-1
Abstract: Microcapsules and microgels consisting of macromolecular networks have received increasing attention due to their biomedical and pharmaceutical applications. Protein microgels and in particular silk-based microcapsules have desirable properties due to their biocompatibility and lack of… read more here.
Keywords: shear mediated; transition; mediated sol; shear stress ... See more keywords
Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function
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DOI: 10.3390/ijms24087386
Abstract: Implantable Cardiovascular Therapeutic Devices (CTD), while lifesaving, impart supraphysiologic shear stress to platelets, resulting in thrombotic and bleeding coagulopathy. We previously demonstrated that shear-mediated platelet dysfunction is associated with downregulation of platelet GPIb-IX-V and αIIbβ3… read more here.
Keywords: hemostatic function; morphology; shear mediated; heterogeneity morphology ... See more keywords