ADAM10 sheddase activation is controlled by cell membrane asymmetry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz008
Abstract: Abstract Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer’s disease. The mechanisms underlying ADAM10 sheddase activation are incompletely understood. Here, we show that transient exposure of the… read more here.
Keywords: activation controlled; adam10 sheddase; sheddase activation; sheddase ... See more keywords
Treatment with the ADAM17 sheddase inhibitor, phosphatidylserine, improves endothelial function and reduces arterial stiffness in diabetic mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733711
Abstract: Patients with type 2 diabetes (T2D) have an increased incidence of cardiovascular disease (CVD) morbidity and mortality. Indeed, CVD is the primary cause of death in T2D. Arterial stiffness and hypertension are both implicated in… read more here.
Keywords: physiology; mice; arterial stiffness; treatment ... See more keywords
System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72947
Abstract: Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. DR is a multifactorial disease involving changes in retinal microvasculature and neuronal layers, and aberrations in vascular endothelial growth factors… read more here.
Keywords: ectodomain shedding; vitreous proteome; diabetic retinopathy; angiogenesis ... See more keywords