Epigallocatechin-3-gallate downregulates lipopolysaccharide signaling in human aortic endothelial cells by inducing ectodomain shedding of TLR4.
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DOI: 10.1016/j.ejphar.2019.172692
Abstract: Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea leaves, has anti-inflammatory effects. In this study, we investigated the mechanism by which EGCG attenuates the effects of lipopolysaccharides (LPS), an agonist of toll-like receptor 4… read more here.
Keywords: shedding tlr4; ectodomain shedding; epigallocatechin gallate; egcg ... See more keywords