Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages?
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-018-1104-x
Abstract: AbstractSheep model is the most favourable choice for animal study for functional evaluation of the cervical fusion prostheses before clinical application; however, significantly large differences between sheep and human existed in terms of morphological characteristics… read more here.
Keywords: functional evaluation; sheep model; model; evaluation cervical ... See more keywords
Assessment of the immunogenicity of the leptospiral LipL32, LigAni, and LigBrep recombinant proteins in the sheep model.
Sign Up to like & getrecommendations! Published in 2019 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2019.05.012
Abstract: Veterinary leptospirosis vaccines are composed of bacterins and present limitations, for example, the need for bacteriological culture and serovar-dependent immunity. Recombinant antigens represent a promising alternative. LigAni, LigBrep, and LipL32 proteins have been shown to… read more here.
Keywords: lipl32; recombinant proteins; ligani ligbrep; group ... See more keywords
Associations between fetal heart rate variability and umbilical cord occlusions‐induced neural injury: An experimental study in a fetal sheep model
Sign Up to like & getrecommendations! Published in 2022 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.14352
Abstract: This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic–ischemic encephalopathy in a fetal sheep model. read more here.
Keywords: fetal heart; sheep model; rate variability; fetal sheep ... See more keywords
Sheep model of haemodialysis treatment
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DOI: 10.1177/0023677217718861
Abstract: More than two million patients received haemodialysis (HD) in 2013. Many methods for improving dialysis therapy outcomes have been tested. Nevertheless, patients continue to experience high morbidity and mortality rates. We aimed to develop an… read more here.
Keywords: sheep model; treatment; model haemodialysis; physiology ... See more keywords
Absorbance or organization into ankylosis: a microarray analysis of haemarthrosis in a sheep model of temporomandibular joint trauma
Sign Up to like & getrecommendations! Published in 2021 at "BMC Oral Health"
DOI: 10.1186/s12903-021-02033-w
Abstract: Background Traumatic haemarthrosis was hypothesized to be the etiology of temporomandibular (TMJ) ankylosis. Here, taking haematoma absorbance as a control, we aimed to reveal the molecular mechanisms involved in haematoma organizing into ankylosis using transcriptome… read more here.
Keywords: sheep model; absorbance; microarray; haemarthrosis ... See more keywords
Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/en.2019-00386
Abstract: Polycystic ovary syndrome (PCOS) is a common condition of reproductive aged women. In a well-validated sheep model of PCOS, testosterone (T) treatment of pregnant ewes culminated in placental insufficiency and intrauterine growth restriction of offspring.… read more here.
Keywords: ovary syndrome; polycystic ovary; placental function; sheep model ... See more keywords
Developmental programming of the neuroendocrine axis by steroid hormones: Insights from the sheep model of PCOS
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1096187
Abstract: The reproductive neuroendocrine system is a key target for the developmental programming effects of steroid hormones during early life. While gonadal steroids play an important role in controlling the physiological development of the neuroendocrine axis,… read more here.
Keywords: steroid hormones; sheep model; neuroendocrine axis; developmental programming ... See more keywords
Fluoxetine-induced perinatal morbidity in a sheep model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.955560
Abstract: Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressants used by pregnant women. However, adverse pregnancy outcomes have been described in women taking SSRI during pregnancy—placental lesions, premature birth, poor neonatal adaptation. We aimed… read more here.
Keywords: day; fluoxetine; gestation; sheep model ... See more keywords
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatment: In Vivo Rabbit Toxicological Tests and In Vivo Efficacy Tests in a Sheep Model
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DOI: 10.3390/bioengineering10020206
Abstract: The treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing… read more here.
Keywords: osteomyelitis; sheep model; treatment; toxicological tests ... See more keywords
The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders
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DOI: 10.3390/biology11091251
Abstract: Simple Summary We review the value of large animal models for improving the translation of biomedical research for human application, focusing primarily on sheep. Abstract An essential aim of biomedical research is to translate basic… read more here.
Keywords: large animal; sheep model; model; sheep large ... See more keywords
Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9101344
Abstract: Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously.… read more here.
Keywords: fetal hypoxia; miniaturized electrochemical; electrochemical sensors; sheep model ... See more keywords