Sclerotiorin stabilizes the assembly of non-fibrillar Abeta42 oligomers with low toxicity, seeding activity and beta-sheet content.
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DOI: 10.1016/j.jmb.2020.01.033
Abstract: The self-assembly of the 42-residue amyloid-β peptide, Aβ42, into fibrillar aggregates is associated with neuronal dysfunction and toxicity in Alzheimer's disease (AD) patient brains, suggesting that small molecules acting on this process might interfere with… read more here.
Keywords: sheet content; low toxicity; seeding activity; sheet ... See more keywords